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Human Tissue kallikrein Recombinant


accession:  P06870
   Size A     10ug   $ 160
   Size B      50ug  $680
   Size C      200ug  $ 1950
Domain  : 
Gene  :  KLK1
Catalog no. :  RKP06870



Optimized DNA sequence encoding Human Tissue kallikrein - KLK1 (PRO19-SER262) preprotein including a C-terminal His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant Human Kallikrein-11 (KLK11) is a protein consisting of 250 amino acid residue subunits,due to glycosylation migrates as an approximately as 40kDa band protein on reduced SDS-PAGE.

>95%, as determined by SDS-PAGE and HPLC

Biological Activity:
The activity was tested by the ability to cleave a fluorogenic substrate PFR-AMC .The specific activity was measured to be 1.2 nmole/ug/min
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant Tissue kallikrein is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Recombinant Tissue kallikrein (KLK1) can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.


Tissue kallikrein

Tissue kallikrein is a serine protease that contributes to bradykinin production and causes flow- dependent arterial dilation through activation of bradykinin B2 receptors coupled with endothelial nitric oxide release.7 The kallikrein-kinin system (KKS) is one of the main mechanisms controlling systemic and local hemodynamics

Related Publications:
Tissue kallikrein attenuates choroidal neovascularization via cleavage of vascular endothelial growth factor
Invest. Ophthalmol. Vis. Sci., Jan 2013; 54: 274 - 279.
association Tissue kallikrein with the severity of coronary artery disease
Heart, Oct 2012; 98: E269.
human Tissue kallikrein 1 gene overexpression improves ventricular remodelling with myocardial infarction in rats
Heart, Oct 2012; 98: E57 - E58.
Tissue kallikrein activation of the epithelial na channel
Am J Physiol Renal Physiol, Aug 2012; 303: F540 - F550.
Tissue kallikrein suppresses laser-induced choroidal neovascularization in mice
Invest. Ophthalmol. Vis. Sci., Mar 2012; 53: 439.

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Purified Polyclonal
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