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Human Olfactomedin-4 Recombinant

OLFM4

accession:  Q6UX06
   Size A     10ug   $ 160
   Size B      50ug  $680
   Size C      200ug  $ 1950
Domain  : 
Gene  :  OLFM4
Catalog no. :  RKQ6UX06

 

Source:

Optimized DNA sequence encoding mature chain of human Olfactomedin-4 (OLFM4) (Asp 21 - GLN510) including an C terminal His tag was expressed in HEK293 cells.


 
Molecular weight:

Recombinant human Olfactomedin-4 is a protein consisting of 495 amino acid residue subunits,due to glycosylation migrates as an approximately 65kDa band protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant  human Olfactomedin-4 is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
Recombinant Olfactomedin-4 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

Olfactomedin-4

OLFM4 (also called hGC-1 and GW112) is a member of the olfactomedin family, which is characterized by the presence of an olfactomedin domain in the C terminus (5). Olfactomedin-related proteins have distinct tissue expression patterns and diverse cellular functions. OLFM4 is expressed in epithelial cells of the prostate, small intestine, colon, and cells in the bone marrow. It is also expressed in several cancers and up- regulated in epithelial cells during inflammation

Related Publications:
olfactomedin 4 inhibits cathepsin c-mediated protease activities, thereby modulating neutrophil killing of staphylococcus aureus and escherichia coli in mice
J. Immunol., Sep 2012; 189: 2460 - 2467.
olfactomedin 4 defines a subset of human neutrophils
J. Leukoc. Biol., Mar 2012; 91: 495 - 500.
olfactomedin 4 suppresses prostate cancer cell growth and metastasis via negative interaction with cathepsin d and sdf-1
Carcinogenesis, Jul 2011; 32: 986 - 994.
olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis
Blood, Dec 2010; 116: 4938 - 4947.
olfactomedin 4, an indicator of the existence of neutrophil subsets.
Blood (ASH Annual Meeting Abstracts), Nov 2010; 116: 3775.




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