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Mouse B7-H4 Recombinant

VTCN1

accession:  Q7TSP5
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  : 
Gene  :  VTCN1
Catalog no. :  RKQ7TSP5

 

Source:

Optimized DNA sequence  encoding mature chain of  mouse B7-H4 (PHE29 - SER256) including a C-terminal His tag was expressed in HEK293 cells.


 
Molecular weight:

Recombinant mouse B7H4 (VTCN1) is a protein consisting of 232 amino acid residue subunits,due to glycosylation migrates as an approximately as 50kDa band protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 

              
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant mouse B7-H4 is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
Recombinant B7-H4(B7S1) can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

B7-H4

B7-H4 (B7x and B7S1) is a member of the B7-CD28 cosignaling molecule family/immunoglobulin superfamily with signature IgV and IgC regions in the extracellular domain, a single transmembrane domain, and an intracellular domain.3 Although the mRNA for B7-H4 is broadly detectable in the majority of normal tissues and cell types, its cell surface expression is relatively rare.4–8 Expression of B7-H4 protein, however, can be induced in vitro on hematopoietic cells.In contrast to its limited distribution in normal tissues, constitutive cell surface and cytoplasmic expression of B7-H4 is found on various cultured cancer lines and freshly isolated human carcinomas of breast, lung, ovarian, and kidney

Related Publications:
genetic variation in vtcn1 (b7-h4) is associated with course of disease in juvenile idiopathic arthritis
Ann Rheum Dis, Dec 2013; 10.1136/annrheumdis-2013-204466.
novel recombinant human B7-H4 antibodies overcome tumoral immune escape to potentiate t-cell antitumor responses
Cancer Res., Aug 2013; 73: 4820 - 4829.
host B7-H4 regulates antitumor t cell responses through inhibition of myeloid-derived suppressor cells in a 4t1 tumor transplantation model
J. Immunol., Jun 2013; 190: 6651 - 6661.
sat0180 b7-h4 expression of renal tubular epithelial cells in patients with lupus nephritis
Ann Rheum Dis, Jun 2012; 71: 532.
enhanced t cell immunity by B7-H4 downregulation in nonsmall-cell lung cancer cell lines
Journal of International Medical Research, Apr 2012; 40: 497 - 506.




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Antibodies:
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