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Mouse EpCAM Recombinant


accession:  Q99JW5
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  : 
Gene  :  EpCAM
Catalog no. :  RKQ99JW5



Optimized DNA sequence  encoding  extracellular domain of Mouse Epithelial cell adhesion molecule (EpCAM)(GLN24 - THR265)including a C-terminal His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant Mouse EpCAM is a protein consisting of 249 amino acid residue subunits,due to glycosylation migrates as an approximately 35kDa protein on reduced SDS-PAGE.

>95%, as determined by SDS-PAGE and HPLC
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant Mouse EpCAM is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

Recombinant  EpCAM can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.



Epithelial cell adhesion molecule (EpCAM), also known as CD326, TACSTD1, and TROP- 1, is a type I transmembrane glycoprotein that was first identified as a tumor- associated antigen (1). EpCAM is highly expressed by many carcinomas, and its possible involvement in tumor development, progression, and metastasis has been extensively studied. EpCAM is also widely expressed by developing epithelia in normal individuals, and high levels persist in some epithelia in adults . Although EpCAM has been less extensively studied in normal tissues and nontransformed cells than in cancer, there are indications that EpCAM influences epithelial homeostasis. Expression of EpCAM promotes aggregation of fibroblasts in suspension, suggesting that EpCAM can function as an intercellular adhesion molecule

Related Publications:
functional consequences of EpCAM mutation in mice and men
Am J Physiol Gastrointest Liver Physiol, Feb 2014; 306: G278 - G288.
psma, EpCAM, vegf, and grpr as imaging targets in locally recurrent prostate cancer after radiotherapy.
ASCO Meeting Abstracts, Feb 2014; 32: 201.
increasing the antitumor effect of an EpCAM-targeting fusion toxin by facile click pegylation
Mol. Cancer Ther., Feb 2014; 13: 375 - 385.
EpCAM expression in lymph node and bone metastases of prostate carcinoma: a pilot study.
ASCO Meeting Abstracts, Feb 2014; 32: 165.
sry hmg box protein 9-positive (sox9+) epithelial cell adhesion molecule-negative (EpCAM-) biphenotypic cells derived from hepatocytes are involved in mouse liver regeneration
J. Biol. Chem., Jan 2014; 10.1074/jbc.M113.517243.

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