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Rabbit Anti IL-17 Polyclonal

IL-17

accession:  Q16552
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA16552
Source:
Optimized DNA sequence encoding Human Interleukin-17A mature chain was expressed in Escherichia Coli.

 
Molecular weight:

Native human Interleukin17A, generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 16kDa.

Recombinant IL-17A is a disulfide-linked homodimeric protein consisting of two 137 amino acid residue subunits, and migrates as an approximately 31kDa protein under non-reducing conditions and as a 16 kDa protein under reducing conditions in SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
The ED(50) was determined by the dose-dependent  proliferation of induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/ml., corresponding to a specific activity of > 5 x 105 units/mg

 
Protein Sequence:
        10         20         30         40         50         60 
MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN IHNRNTNTNP 

        70         80         90        100        110        120 
KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI NADGNVDYHM NSVPIQQEIL 

       130        140        150 
VLRREPPHCP NSFRLEKILV SVGCTCVTPI VHHVA 
(*)Complete precursor sequence shown, expressed chain highlighted
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human Interleukin-17 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

 

IL-17



Related Publications:
pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma
J. Exp. Med., Sep 2009; 206: 2191 - 2204.
complex regulation of tartrate-resistant acid phosphatase (trap) expression by interleukin 4(IL-4): IL-4 indirectly suppresses receptor activator of nf -kappab ligand (rankl)- mediated trap expression but modestly induces its expression directly
J. Biol. Chem., Sep 2009; 10.1074/jbc.M109.001016.
gm-csf and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through m-csf receptor shedding by up-regulation of tnf- converting enzyme (tace)
Blood, Sep 2009; 10.1182/blood-2009-04-215020.
ship represses the generation of il-3-induced m2 macrophages by inhibiting IL-4 production from basophils
J. Immunol., Sep 2009; 183: 3652 - 3660.
mycobacterium tuberculosis culture filtrate proteins plus cpg-odn confer protection to bcg primed mice by inhibiting IL-4 secretion
Infect. Immun., Sep 2009; 10.1128/IAI.00580-09.




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