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Rabbit anti Endostatin Polyclonal

Endostatin

accession:  P39060
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA39060
Applications:
Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
 
Source:
Polyclonal Endostatin antibody was produced from sera of rabbits  immunized with synthetic protein containing Endostatin  antigenic determinants. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein A affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

Endostatin

Endostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. This factor of 20 kDa is found in the conditioned medium of the hemangioendothelioma cell line EOMA.Systemic therapy with endostatin causes a nearly complete suppression of tumor induced angiogenesis, Continued administration of endostatin maintains the tumors in a state of dormancy and tumors begin to grow again when the factor is withdrawn.

Related Publications:
Endostatin suppresses igf-ii-mediated signaling and invasion of human extravillous trophoblasts
Endocrinology, Nov 2011; 152: 4431 - 4442.
cysteine cathepsins s and l modulate anti-angiogenic activities of human Endostatin
J. Biol. Chem., Oct 2011; 286: 37158 - 37167.
angiopoietin-1 and Endostatin levels in cord plasma predict the development of bronchopulmonary dysplasia in preterm infants
J Trop Pediatr, Oct 2011; 57: 385 - 388.
dual targeting of tumor angiogenesis and chemotherapy by Endostatin–cytosine deaminase–uracil phosphoribosyltransferase
Mol. Cancer Ther., Aug 2011; 10: 1327 - 1336.
prognostic significance of the angiogenic factors angiogenin, endoglin and Endostatin in cervical cancer
Anticancer Res, Aug 2011; 31: 2651 - 2655.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
Related Products:
product_icon_7.jpg Rabbit anti Endostatin Polyclonal
 
 
 
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