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Rabbit anti phospho CREB1 Polyclonal

CREB-1

accession:  P16220
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA16220
Applications:
Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
 
CREB1 western blot/WB

WB analysis mouse hippocampal tissue lysate expressing phospho CREB1. 
Cat# RPA16220 was used as primary antibody.

 

 

 

il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
 
CREB1 Immunohistochemistry/IHC

Immunohistochemical analysis of frozen mouse hyppocampal sections expressing CREB1. 
Cat# RPA16220 was used as primary antibody, dilution 1:200.

 

 

 

BCL-2 Immunohistochemistry/IHC

Immunohistochemical analysis of FFPE mouse thymocytes  expressing phospho CREB-1. 
Cat# RPA16220 was used as primary antibody, dilution 1:500.

 

 

 

 
Source:
Polyclonal p-CREB-1 antibody was produced from sera of mice  immunized with synthetic protein containing residues surrounding ser133 . 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CREB-1

The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1,ATF- 2,ATF-3and ATF-4. these transcription factors share highly-related COOH terminal leucine zipper demerization and basic DNA bindings but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in cerain instances they also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. It has recentlybeen shown that protein kinase A- mediated CREB phosphorylation results in its binding to a 265kDa nuclear protein designated CBP (CREB-binding protein), which may reprecent a CREB co-activator.

Related Publications:
CREB-1 is recruited to and mediates upregulation of the cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation
Mol. Cell. Biol., Apr 2008; 28: 2446 - 2459.
il-10 regulation by hiv-tat in primary human monocytic cells: involvement of calmodulin/calmodulin-dependent protein kinase-activated p38 mapk and sp-1 and CREB-1 transcription factors
J. Immunol., Jan 2007; 178: 798 - 807.
intracellular hiv-tat expression induces il-10 synthesis by the CREB-1 transcription factor through ser133 phosphorylation and its regulation by the erk1/2 mapk in human monocytic cells
J. Biol. Chem., Oct 2006; 281: 31647 - 31658.
requirement of smad3 and CREB-1 in mediating transforming growth factor- (tgf) induction of tgf3 secretion
J. Biol. Chem., Oct 2006; 281: 29479 - 29490.
impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene
Mol. Pharmacol., Dec 2004; 66: 1536 - 1543.




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Antibodies:
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