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Rabbit anti IL-5 Polyclonal

IL-5

accession:  P05113
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA05113
Applications:
il-2 elisa Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
 
Source:
Polyclonal Interleukin-5 antibody was produced from sera of rabbits  immunized with synthetic protein containing Interleukin-5 antigenic determinants. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

IL-5

Interleukin-5 is a specific hematopoietic growth factor that is responsible for the growth and differentiation of eosinophils. IL-5 promotes the growth of immature hematopoietic progenitor cells BFU-E while it causes differentiation of CFU-E the proliferation of which is inhibited by IL-5. IL-5 strongly stimulates the proliferation, cell activation, and differentiation of eosinophils. B-cells can be made responsive to IL5 by treatment with suboptimal doses of IL1. Interleukin-5 also promotes the generation of cytotoxic T-cells from thymocytes. In thymocytes IL-5 induces the expression of high affinity IL2 receptors. In contrast to human Interleukin-5, mouse IL-5 also acts on B-cells. It induces the proliferation of pre-activated B-cells and their differentiation. High affinity and low affinity receptors for IL5 are expressed in all hematopoietic and lymphoid cells.The low affinity receptor, CD125, has a molecular mass of 50 kDa (p60) . The introduction of p60 into these cells generates a high affinity IL-5 receptor. The second subunit of the IL-5 receptor is identical with the larger subunit of the receptor for the colony stimulating factor GM-CSF (CD131). This subunit is involved also in the generation of a high affinity receptor for IL-3 and is being referred to as common beta.

Related Publications:
systemic overexpression of ifn- and IL-5 exacerbates early phase reaction and conjunctival eosinophilia, respectively, in experimental allergic conjunctivitis
Br J Ophthalmol, Aug 2009; 10.1136/bjo.2009.162594.
regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output
Blood, Aug 2009; 10.1182/blood-2009-03-208850.
il-33 induces antigen-specific IL-5+ t cells and promotes allergic-induced airway inflammation independent of il-4
J. Immunol., Oct 2008; 181: 4780 - 4790.
in vitro study of interleukin-5 (IL-5) in human eosinophilic chronic rhinosinusitis cell culture
In Vivo, Sep 2008; 22: 549 - 556.
separate endocytic pathways regulate IL-5 receptor internalization and signaling
J. Leukoc. Biol., Aug 2008; 84: 499 - 509.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
Related Products:
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product_icon_8.jpg Rat Interleukin-5 Recombinant
product_icon_8.jpg Mouse Interleukin-5 Recombinant
product_icon_7.jpg Rabbit anti IL-5 Polyclonal
product_icon_8.jpg Human IL-5 receptor alpha Recombinant (CD125)
 
 
 
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