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Rabbit anti IL-3 Polyclonal


accession:  P08700
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA08700
il-2 elisa Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
Polyclonal Interleukin-3 antibody was produced from sera of rabbits  immunized with synthetic protein containing Interleukin-3 antigenic determinants. 
Species reactivity:

Serum IgG fraction was purified by Protein G affinity chromatography.

Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.


This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.


IL3 is produced mainly by T- cells following cell activation by antigens and mitogens, but also by keratinocytes, NK-cells, mast cells, endothelial cells, and monocytes. The analysis of bacterial- derived recombinant IL3 shows that glycosylation is not required for the activity of IL3. IL3 sequences are evolutionarily less well conserved. Human and murine IL3 show approximately 29 % homology at the protein level while murine and rat IL3 show approximately 54 % homology. IL3-alpha and IL3- beta are two isoforms of rat IL3. IL3 receptors are expressed on macrophages, mast cells, eosinophils, megakaryocytes, basophils, bone marrow progenitor cells, and various myeloid leukemia cells. IL3/receptor complexes have a Kdis of 10-9 - 10-10 M. Binding of IL3 to its receptor causes specific phosphorylation of a 150 kDa membrane glycoprotein.

Related Publications:
a conserved insulator that recruits ctcf and cohesin exists between the closely related but divergently regulated Interleukin-3 and granulocyte-macrophage colony-stimulating factor genes
Mol. Cell. Biol., Apr 2009; 29: 1682 - 1693.
a new isoform of Interleukin-3 receptor with novel differentiation activity and high affinity binding mode
J. Biol. Chem., Feb 2009; 284: 5763 - 5773.
identification of 24p3 as a direct target of foxo3a regulated by Interleukin-3 through the phosphoinositide 3-kinase/akt pathway
J. Biol. Chem., Jan 2009; 284: 2187 - 2193.
Interleukin-3 (il-3)-induced c-fos activation is modulated by gab2-calcineurin interaction
J. Biol. Chem., Aug 2008; 283: 23505 - 23509.
Interleukin-3 promotes expansion of hemopoietic-derived cd45+ angiogenic cells and their arterial commitment via stat5 activation
Blood, Jul 2008; 112: 350 - 361.

by class:
Growth factors
CD markers
Viral Antigens
by species:
Purified Polyclonal
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