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Rabbit anti IL-18 Polyclonal

IL-18

accession:  Q14116
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA14116
Applications:
Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
il-2 elisa
IL-18 IHC

Immunohistochemical analysis of IL-18 expression in formalin fixed paraffin embedded sections of Rat brain tissue.

Cat# RPA14116  was used as primary antibody, dilution 1:200.

 
Source:
Polyclonal Interleukin-18 antibody was produced from sera of rabbits  immunized with synthetic protein containing Interleukin-18 N-terminus antigenic determinants. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

IL-18

IL18 is synthesized as a biologically inactive precursor protein that has limited biological activity. The proform of IL18 is processed by one of the caspases, Caspase-1, to generate the 18 kDa bioactive molecule. IL-18 is produced during the acute immune response by macrophages and immature dendritic cells. Interleukin-18 is expressed by a variety of immune and non-immune cells, including monocytes and macrophages. IL18 is one of the pro- inflammatory cytokines. The activities of IL18 appear to be species specific. An important function of IL18 is the regulation of functionally distinct subsets of T-helper cells required for cell mediated immune responses (Nakanishi et al, 2001). IL18 functions as a growth and differentiation factor for Th1 cells. IL18 up-regulates FAS ligand mediated cytotoxic activitiy of murine natural killer cells. IL-18 is part of a complex regulatory circuit involved in causing cell death by apoptosis.

Related Publications:
IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction
PNAS, Sep 2009; 10.1073/pnas.0908924106.
IL-18 and urinary ngal predict dialysis and graft recovery after kidney transplantation
J. Am. Soc. Nephrol., Sep 2009; 10.1681/ASN.2009030264.
a functional polymorphism in IL-18 is associated with severity of bronchial asthma
Am. J. Respir. Crit. Care Med., Sep 2009; 10.1164/rccm.200905-0652OC.
il-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection
J. Immunol., Sep 2009; 183: 3324 - 3331.
neutrophil chemokines and their role in IL-18-mediated increase in neutrophil o2– production and intestinal edema following alcohol intoxication and burn injury
Am J Physiol Gastrointest Liver Physiol, Aug 2009; 297: G340 - G347.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
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