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Rabbit anti CD8 Polyclonal

CD8

accession:  P01732
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA01732
Applications:
Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
 

Immunohistochemical analysis of FFPE rat small intestines tissue showing localization of CD8 .

Cat# RPA01732 was used as primary antibody, dilution 1:200.

 

 

 

 
Source:
Polyclonal CD8 antibody was produced from sera of rabbits  immunized with synthetic protein containing CD8A antigenic determinants. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD8

The cell surface glycoprotein CD8 plays an important role in the development and function of MHC3 class I-restricted T cells. CD8 fulfils its function through interacting via its extracellular domain with MHC class I proteins and via its intracellular domain with the tyrosine kinase Lck (1, 2). An interaction of both the T cell receptor (TCR) and CD8 with MHC proteins enhances the adhesion between the T cell and the antigen- presenting cell.The coreceptor CD8 is expressed as a CD8ab heterodimer on major histocompatibility complex class I-restricted TCRab T cells, and as a CD8aa homodimer on subsets of memory T cells, intraepithelial lymphocytes, natural killer cells, and dendritic cells.

Related Publications:
extralymphoid CD8+ t cells resident in tissue from simian immunodeficiency virus sivmac239nef-vaccinated macaques suppress sivmac239 replication ex vivo
J. Virol., Apr 2010; 84: 3362 - 3372.
dendritic cell migration limits the duration of CD8+ t-cell priming to peripheral viral antigen
J. Virol., Apr 2010; 84: 3586 - 3594.
recombinant yellow fever vaccine virus 17d expressing simian immunodeficiency virus sivmac239 gag induces siv-specific CD8+ t-cell responses in rhesus macaques
J. Virol., Apr 2010; 84: 3699 - 3706.
CD8 t cell cross-reactivity networks mediate heterologous immunity in human ebv and murine vaccinia virus infections
J. Immunol., Mar 2010; 184: 2825 - 2838.
diversity of the CD8+ t cell repertoire elicited against an immunodominant epitope does not depend on the context of infection
J. Immunol., Mar 2010; 184: 2958 - 2965.




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by species:
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mouse
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Antibodies:
Purified Polyclonal
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