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Rabbit anti CD4 Polyclonal

CD4

accession:  P07766
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA01730
Applications:
ELISA:Use at a concentration range of 1-2ug/ml.
il-2 elisa WB: A suitable range of concentrations of this antibody for WB  is 2-10 µg/ml.
il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
 
CD4 IHC

Immunohistochemical analysis of FFPE human colorectal cancer sections showing lymphocyte expression of CD4.

Cat# RPA01730 was used as primary antibody, dilution 1:400, DAB chromogenic staining.


CD4 IHC

Immunohistochemical analysis of FFPE mouse kidney sections showing lymphocyte expression of CD4.

Cat# RPA01730 was used as primary antibody, dilution 1:200, DAB chromogenic staining.


 
Source:
Polyclonal CD4 antibody was produced from sera of rabbits  immunized with synthetic protein containing CD4 antigenic determinants. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD4

CD4 is a 55 kDa transmembrane glycoprotein belonging to the immunoglobulin superfamily. In humans CD4 is expressed of peripheral T-cells, thymocytes, on macrophages and granulocytes. CD4 acts as a cellular adhesion molecule binding MHC class 2 molecules. It stabilizes the interaction of MHC class 2 restricted T- cells and antigen-presenting cells expressing an antigen in combination with a MHC class 2 molecule. Interactions of CD4 with MHC class 2 molecules are crucial during thymic development and subsequently for the function of single- positive CD4(+), CD8(-) T- lymphocytes. CD4 functions as an effector molecule for intracellular signal transduction. In T- lymphocytes CD4 has been found to be associated with tyrosine kinase lck which phosphorylates a number of other cell surface proteins and is involved probably in transducing the intracellular signal when these proteins are bound to their receptors.

Related Publications:
hiv-infected ugandan adults taking antiretroviral therapy with CD4 counts >200 cells/μl who discontinue cotrimoxazole prophylaxis have increased risk of malaria and diarrhea
Clinical Infectious Diseases, Apr 2012; 54: 1204 - 1211.
CD4+ type ii nkt cells mediate icos and programmed death-1–dependent regulation of type 1 diabetes
J. Immunol., Apr 2012; 188: 3138 - 3149.
spatial alterations between CD4+ t follicular helper, b, and cd8+ t cells during simian immunodeficiency virus infection: t/b cell homeostasis, activation, and potential mechanism for viral escape
J. Immunol., Apr 2012; 188: 3247 - 3256.
dissection of a circulating and intrahepatic CD4+foxp3+ t-cell subpopulation in chronic hepatitis b virus (hbv) infection: a highly informative strategy for distinguishing chronic hbv infection states
The Journal of Infectious Disease, Apr 2012; 205: 1111 - 1120.
mhc class ib-restricted cd8 t cells differ in dependence on CD4 t cell help and cd28 costimulation over the course of mouse polyomavirus infection
J. Immunol., Apr 2012; 188: 3071 - 3079.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
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