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Rabbit anti CD31 (PECAM1) Polyclonal

CD31

accession:  P16284
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA16284
Applications:
Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
 
CD31 IHC

Immunohistochemical analysis of CD31-positive microvessels in FFPE Human malignant melanoma cell line, A375.

Cat#RPA16284 was used as primary antibody, dilution 1:200, DAB chromogen substrate.

CD31 IHC

Immunohistochemical analysis of mouse CD31 expression in FFPE vascular endothelial melanoma cell.

Cat#RPA16284 was used as primary antibody,  dilution 1:200, DAB chromogen substrate..

 
Source:
PolyclonalCD31 antibody was produced from sera of rabbits  immunized with synthetic protein containing CD31 antigenic determinants. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD31

Platelet endothelial cell adhesion molecule (PECAM-1, CD31) is a 130 kD glycoprotein that is constitutively expressed by endothelial cells and by platelets, neutrophils, monocytes, and some T- lymphocytes. It is an integral transmembrane protein that belongs to the immunoglobulin superfamily and that mediates both homotypic and heterotypic cell adhesion. These functions have implicated CD31 in a variety of important biological processes including inflammation, angiogenesis and wound healing.In particular, CD31 has an important role in neutrophil and monocyte emigration across vascular endothelium, processes that can be inhibited, both in vitro and in vivo, with anti-CD31 antibodies.

Related Publications:
prognostic and predictive impact of expression of the angiogenic markers cd105 and CD31 expression in patients with high risk breast cancer (hrbc).
Cancer Res., Dec 2009; 69: 2154.
cd38/CD31, the ccl3 and ccl4 chemokines, and cd49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival
Cancer Res., May 2009; 69: 4001 - 4009.
circulating monocytes expressing CD31: implications for acute and chronic angiogenesis
Am. J. Pathol., May 2009; 174: 1972 - 1980.
il-7 sustains CD31 expression in human naive cd4+ t cells and preferentially expands the CD31+ subset in a pi3k-dependent manner
Blood, Mar 2009; 113: 2999 - 3007.
transcriptional profiling of CD31+ cells isolated from murine embryonic stem cells
Genes Cells, Feb 2009; 14: 243 - 260.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
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product_icon_8.jpg Mouse CD31 Recombinant (PECAM1)
product_icon_8.jpg Human CD31 Recombinant (PECAM1) Fc tag
 
 
 
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