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Rabbit Anti IL-7 Polyclonal

IL-7

accession:  P13232
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C       $
Clone  : 
Isotype  :  IL7
Catalog no. :  RPA13232
Applications:
il-2 elisa Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
   
Source:
Polyclonal Interleukin-7 antibody was produced from sera of rabbits  immunized with synthetic protein containing N- terminal Interleukin-7 antigenic determinants. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity. 

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

IL-7

IL7 is secreted constitutively into the conditioned medium of adherent bone marrow stromal cells and thymic cells. Mouse and human keratinocytes have been shown also to express and secrete IL7.Human (152 amino acids; 17.4 kDa) and murine IL7 (129 amino acids) show 60 % sequence homology at the protein level. The human IL7 receptor is an integral strongly glycosylated membrane proteins of 76 kDa expressed on activated T-cells. This receptor has been designated as CD127. IL7 receptors are expressed on pre-B-cells and their progenitors. They are not expressed on mature B-cells. IL7 receptors are expressed also on bone marrow macrophages. Functional IL7 receptors are found on the cell surface of multiphenotypic, biphenotypic, and immature lymphoid progenitors of B- cells with the gene arrangement of the heavy immunoglobulin chain such as those observed in the germ line

Related Publications:
tslp and IL-7 use two different mechanisms to regulate human cd4+ t cell homeostasis
J. Exp. Med., Sep 2009; 206: 2111 - 2119.
self-peptides prolong survival in murine autoimmunity via reduced il-2/IL-7-mediated stat5 signaling, cd8 coreceptor, and v2 down-regulation
J. Immunol., Sep 2009; 183: 3130 - 3138.
rap signaling is crucial for the competence of IL-7 response and the development of b-lineage cells
Blood, Aug 2009; 114: 1768 - 1775.
cutting edge: IL-7 regulates the peripheral pool of adult ror+ lymphoid tissue inducer cells
J. Immunol., Aug 2009; 183: 2217 - 2221.
effect of end-stage renal disease on b-lymphocyte subpopulations, IL-7, baff and baff receptor expression
Nephrol. Dial. Transplant., Aug 2009; 10.1093/ndt/gfp397.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
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product_icon_8.jpg Human IL-7 receptor Recombinant (CD127)
product_icon_8.jpg Mouse IL-7 receptor Recombinant (CD127)
 
 
 
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