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Human PLGF Recombinant (CHO Cell)


accession:  P21583
   Size A     5ug   $ 160
   Size B      20ug  $480
   Size C      1mg  $ 3500
Domain  :  four helix cytokine core
Gene  :  PIGF
Catalog no. :  RCP49763
Optimized DNA sequence encoding Human Placenta growth factor isoform 1 mature chain fused to a  C terminal His tag was expressed in CHO Cells

Molecular weight:

Native human Placenta growth factor (PLGF) is generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 20 kDa.

Recombinant PLGF  is a  protein consisting of 156 amino acid residue subunits, due to glycosylation migrates as an approximately 30kDa protein under reducing conditions in SDS-PAGE.

>97%, as determined by SDS-PAGE and HPLC

Biological Activity:
The ED(50) was determined by the dose-dependent stimulation of the proliferation of human MDA cells is ≤ 10ug/ml.

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant PLGF  was lyophilized from a 0.2 μm filtered solution inPBS pH 7.0.

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.




Related Publications:
pathological retinal neovascularization is exacerbated by selective pharmacological blockade of vegfr2, but ameliorated by combination with placental growth factor (PLGF) inhibition in the oxygen induced retinopathy (oir) model in mice
Invest. Ophthalmol. Vis. Sci., Jun 2013; 54: 4654.
placental growth factor (PLGF)–specific uptake in tumor microenvironment of 89zr-labeled PLGF antibody ro5323441
J. Nucl. Med., Jun 2013; 54: 929 - 935.
phase i study of anti-PLGF monoclonal antibody (mab) ro5323441 (ro) and anti-vegf mab bevacizumab (bv) in patients with recurrent glioblastoma (gbm).
ASCO Meeting Abstracts, May 2013; 31: 2092.
2.2 plasma placental growth factor (PLGF) in the diagnosis of women with pre-eclampsia requiring delivery within 14 days: the pelican study
Arch. Dis. Child. Fetal Neonatal Ed., Apr 2013; 98: A2.
PLGF: a multitasking cytokine with disease-restricted activity
Cold Spring Harb Perspect Med, Aug 2012; 2: a011056.

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Growth factors
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Purified Polyclonal
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