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Mouse Neuroligin-1 Recombinant

NLGN1

accession:  Q99K10
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  : 
Gene  :  NLGN1
Catalog no. :  RKQ99K10

 

Source:
Optimized DNA sequence  encoding I extracellular domain of Mouse Neuroligin-1 (NLGN1 ) (GLN46 - SER677 )including a C-terminal His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant Mouse Neuroligin-1 (NLG1) is a  protein consisting of 640 amino acid residue subunits,  due to glycosylation migrates as an approximately 110kDa protein on SDS-PAGE.


 
Purity:
>90%, as determined by SDS-PAGE and HPLC
 

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Mouse Neuroligin-1(NLGN1) is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant Neuroligin-1 (NLG1) can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

Neuroligin-1

Neuroligin-1 (NLG1) is a postsynaptic adhesion molecule localized at glutamatergic and GABAergic synapses with a prominent preference for the former . At glutamatergic synapses, NLG1 determines the number of functional NMDAR and is required for normal expression of NMDAR- dependent plasticity . Extracellularly, NLGN1 consists of a long acetylcholinesterase (AChE)- like domain that contains two alternative splice inserts, termed A and B, followed by a short O-Glyc cassette.

Related Publications:
Neuroligin-1 links neuronal activity to sleep-wake regulation
PNAS, Jun 2013; 110: 9974 - 9979.
Neuroligin-1 controls synaptic abundance of nmda-type glutamate receptors through extracellular coupling
PNAS, Jan 2013; 110: 725 - 730.
neurons get the Neuroligin-1 advantage
Sci. Signal., Dec 2012; 5: ec328.
Neuroligin-1 induces neurite outgrowth through interaction with neurexin-1β and activation of fibroblast growth factor receptor-1
FASEB J, Oct 2012; 26: 4174 - 4186.
neuroligin 1 is dynamically exchanged at postsynaptic sites
J. Neurosci., Sep 2010; 30: 12733 - 12744.




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product_icon_8.jpg Mouse Neuroligin-1 Recombinant
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