Optimized DNA sequence encoding I extracellular domain of Human Neuroligin-4 Y linked (NLGN4Y) (GLN 44 - SER676 )including a C-terminal His tag was expressed in HEK293 cells.
Recombinant Neuroligin-4 Y linked (NLGN4Y) is a protein consisting of 640 amino acid residue subunits, due to glycosylation migrates as an approximately 110kDa protein on SDS-PAGE.
>95%, as determined by SDS-PAGE and HPLC
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
Recombinant Human Neuroligin-4 Y linked (NLGN4-Y) is lyophilized from 0.2 μm filtered PBS solution, pH7.2 , 5% Trehalose.
Recombinant Neuroligin-4 Y linked (NLGN4Y) can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.
Avoid repeated freeze/thaw cycles.
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.
Neuroligins (NLs) are
molecules that were
discovered as ligands (or
receptors, depending on the
perspective) for neurexins .
Neurexins, in turn, are a
family of neuronal cell-
adhesion molecules that were
identified as receptors for
the presynaptic neurotoxin
drosophila neuroligin 4 regulates sleep through modulating gaba transmission
15545 - 15554.
Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina
3053 - 3058.
a Neuroligin-4 missense mutation associated with autism impairs Neuroligin-4 folding and endoplasmic reticulum export
10843 - 10854.