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Human ERp19 Recombinant


accession:  O95881
   Size A     20ug   $ 160
   Size B      100ug  $550
   Size C      500ug  $ 1950
Domain  : 
Gene  :  ERp19
Catalog no. :  RKO95881



Optimized DNA sequence encoding Human Endoplasmic reticulum resident protein ERp16/ERp18 (HIS27 - LEU172 ) extracellular domain including a C-terminal His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant Human Endoplasmic reticulum resident protein (ERp16) is a protein consisting of 165 amino acid residue subunits,due to glycosylation migrates as an approximately as 35kDa band protein on reduced SDS-PAGE.

>95%, as determined by SDS-PAGE and HPLC
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant human Endoplasmic reticulum resident protein (ERp19) is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Recombinant Human Endoplasmic reticulum resident protein (ERp18) can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.


Endoplasmic reticulum resident protein

ERp16 (previously designated ERp18, ERp19, or hTLP19). The predicted amino acid sequence of the 172-residue human protein contains an NH2-terminal signal peptide, a thioredoxin-like domain with an active site motif (CGAC), and a COOH-terminal endoplasmic reticulum (ER) retention sequence (EDEL). Analyses indicated that the mature protein (comprising 146 residues) is generated by cleavage of the 26- residue signal peptide and is localized in the lumen of the ER. ERp16 may function as a thiol-disulfide oxidoreductase that is required for correct disulfide bond formation in the ER. Furthermore, the effects of overexpression or depletion of ERp16 on ER stress-induced apoptosis suggest that this protein plays an important role in cellular defense against prolonged ER stress.

Related Publications:
jpdi, a novel endoplasmic reticulum-resident protein containing both a bip-interacting j-domain and thioredoxin-like motifs
J. Biol. Chem., Jan 2003; 278: 2669 - 2676.
binding of antigenic peptide to the endoplasmic reticulum-resident protein gp96/grp94 heat shock chaperone occurs in higher order complexes. essential role of some aromatic amino acid residues in the peptide-binding site
J. Biol. Chem., Mar 2001; 276: 11049 - 11054.
identification of a new endoplasmic reticulum-resident protein recognized by hla-a24-restricted tumor-infiltrating lymphocytes of lung cancer
Cancer Res., Jul 2000; 60: 3550 - 3558.

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Growth factors
CD markers
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Purified Polyclonal
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product_icon_8.jpg Human ERp19 Recombinant
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