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Human EPCR Recombinant, Fc

PROCR

accession:  Q9UNN8
   Size A     20ug   $ 160
   Size B      100ug  $550
   Size C      500ug  $ 1950
Domain  : 
Gene  :  EPCR
Catalog no. :  RKQ9UNN8

 

Source:

Optimized DNA sequence encoding Human Endothelial protein C receptor -EPCR (SER18 - THR209) extracellular domain including an IgG1  C-terminal  tag was expressed in HEK293 cells.


 
Molecular weight:

Recombinant Human Endothelial protein C receptor (PROCR) is a homodimer protein consisting of 433 amino acid residue subunits,due to glycosylation migrates as an approximately as 65kDa band protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant human Endothelial protein C receptor (PROCR) is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
Recombinant Human EPCR can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

Endothelial protein C receptor

The endothelial protein C receptor (EPCR) is a predominant vascular cell receptor. EPCR binds both protein C (PC) zymogen and the serine protease activated protein C (APC) with similar affinity, thereby localizing PC and APC to the cell surface. Although EPCR is considered a nonsignaling receptor because of its short (Arg- Arg-Cys) intracellular tail, it is increasingly recognized as key receptor in the anticoagulant and cytoprotective PC pathways by facilitating (A)PC’s interactions. Binding of PC to EPCR facilitates activation of PC to APC by the thrombin–thrombomodulin complex.APC acts as anticoagulant, and it also conveys cytoprotective functions that require EPCR and protease activated receptor 1 (PAR1), and include antiinflammatory and antiapoptotic activities and endothelial barrier- stabilizing effects.

 




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