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Human uPAR Recombinant

uPAR

accession:  Q03405
   Size A     50ug   $ 160
   Size B      200ug  $480
   Size C      1000ug  $ 1950
Domain  :  UPAR
Gene  :  UPAR
Catalog no. :  RKQ03405

 

Source:

Optimized DNA sequence  encoding Urokinase-type plasminogen activator receptor(LEU23 - ARG303) including a C-terminal His tag was expressed in HEK293 cells.


 
Molecular weight:

Recombinant human Urokinase-type plasminogen activator receptor (uPAR) is a protein consisting of 390 amino acid residue subunits,due to glycosylation migrates as an approximately 50kDa bands protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 
Biological activity:
The activity was tested by the ability of immobilized uPAR to bind recombinant human uPA within a linear range of 20-500 ng/ml in ELISA
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human uPAR is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
Recombinant uPAR can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

Urokinase-type plasminogen activator receptor

The urokinase plasminogen activator receptor (uPAR; also known as PLAUR and CD87) is a cellular receptor for urokinase (uPA), which activates the plasminogen/plasmin activation cycle and its extracellular proteolytic cascade. uPAR also acts through nonproteolytic functions, where associations with a number of cell-bound factors, such as integrins and G-protein- coupled receptors, allow uPAR to stimulate signaling cascades, regulating functions such as cytoskeletal dynamics, cellular adhesion, and cellular migration. Through its proteolytic and nonproteolytic cascades, uPAR is involved in extracellular matrix remodeling, cell migration, coagulation, cellular proliferation, release of inflammatory cytokines, and growth factor activation

Related Publications:
serum soluble Urokinase-type plasminogen activator receptor levels and idiopathic fsgs in children: a single-center report
Clin. J. Am. Soc. Nephrol., Aug 2013; 8: 1304 - 1311.
inactivation of Urokinase-type plasminogen activator receptor (upar) gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice: a new model of experimental scleroderma?
Ann Rheum Dis, Jul 2013; 10.1136/annrheumdis-2013-203706.
op0222 inactivation of Urokinase-type plasminogen activator receptor induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice closely resembling human systemic sclerosis
Ann Rheum Dis, Jun 2013; 72: A127.
the soluble form of lr11 protein is a regulator of hypoxia-induced, Urokinase-type plasminogen activator receptor (upar)-mediated adhesion of immature hematological cells
J. Biol. Chem., Apr 2013; 288: 11877 - 11886.
a flexible multidomain structure drives the function of the Urokinase-type plasminogen activator receptor (upar)
J. Biol. Chem., Oct 2012; 287: 34304 - 34315.




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Antibodies:
Purified Polyclonal
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product_icon_8.jpg Mouse uPAR Recombinant
product_icon_8.jpg Human uPAR Recombinant
 
 
 
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