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Human IGF2BP2 Recombinant

IGF2BP2

accession:  Q9Y6M1
   Size A     10ug   $ 160
   Size B      50ug  $550
   Size C      500ug  $ 3500
Domain  : 
Gene  :  IGF2BP2
Catalog no. :  RKQ9Y6M1

 

Source:

Optimized DNA sequence  encoding peptidase domain of Human Hypoxia inducible factor 1 alpha (MET1 - LYS599) including a C-terminal His tag was expressed in HEK cells


 
Molecular weight:

Recombinant human IGF2BP2 is a protein consisting of 608 amino acid residue subunits, migrates as an approximately 60kDa protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 
 
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human IGF2BP2 is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant IGF2BP2 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

IGF2BP2

IGF2 mRNA-binding protein 2 (IGF2BP2), also known as IMP2, was found to be an HMGA2 target gene during early embryonic development . IGF2BP2 belongs to a family of RNA-binding proteins that contain 6 characteristics of RNA- binding modules, including 2 N-terminal RNA recognition motifs (RRM1 and RRM2) and 4 C-terminal hnRNP K-homology (KH1KH4) domains. Its homolog, IGF2BP1/IMP1, has been shown to be essential for normal embryonic growth and development

Related Publications:
oncogenic nras, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the hmga2–IGF2BP2 pathway
Cancer Res., May 2013; 73: 3041 - 3050.
rna-binding protein IGF2BP2/imp2 is required for laminin-β2 mrna translation and is modulated by glucose concentration
Am J Physiol Renal Physiol, Jul 2012; 303: F75 - F82.
impact of common variants of pparg, kcnj11, tcf7l2, slc30a8, hhex, cdkn2a, IGF2BP2, and cdkal1 on the risk of type 2 diabetes in 5,164 indians
Diabetes, Aug 2010; 59: 2068 - 2074.
genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism
Diabetes, Jun 2009; 58: 1440 - 1444.
association analysis of variation in/near fto, cdkal1, slc30a8, hhex, ext2, IGF2BP2, loc387761, and cdkn2b with type 2 diabetes and related quantitative traits in pima indians
Diabetes, Feb 2009; 58: 478 - 488.




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Antibodies:
Purified Polyclonal
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product_icon_8.jpg Human IGF2BP2 Recombinant
 
 
 
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