Optimized DNA sequence Â encoding peptidase domain of Human Hypoxia inducible factor 1 alpha (MET1 - LYS599) including a C-terminal His tag was expressed in HEK cells
Recombinant human IGF2BP2 is a protein consisting of 608 amino acid residue subunits, migrates as an approximately 60kDa protein on reduced SDS-PAGE.
>95%, as determined by SDS-PAGE and HPLC
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/Âµg(1EU/Âµg).
Recombinant Human IGF2BP2 is lyophilized Â from 0.2 Î¼m filtered PBS solution, Â pH7.2 , Â 5% Trehalose.
Â Â Â Â Â Â Â Â
RecombinantÂ IGF2BP2 can be stored in working aliquots at 2Â° - 8Â° C for one month, or at -20Â°C toÂ -70Â°CÂ for twelve months.
Avoid repeated freeze/thaw cycles.
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.
IGF2 mRNA-binding protein 2
(IGF2BP2), also known as
IMP2, was found to be an
HMGA2 target gene during
early embryonic development
. IGF2BP2 belongs to a
family of RNA-binding
proteins that contain 6
characteristics of RNA-
binding modules, including 2
N-terminal RNA recognition
motifs (RRM1 and RRM2) and 4
C-terminal hnRNP K-homology
(KH1–KH4) domains. Its
homolog, IGF2BP1/IMP1, has
been shown to be essential
for normal embryonic growth
oncogenic nras, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the hmga2–IGF2BP2 pathway
3041 - 3050.
rna-binding protein IGF2BP2/imp2 is required for laminin-β2 mrna translation and is modulated by glucose concentration
Am J Physiol Renal Physiol,
F75 - F82.
impact of common variants of pparg, kcnj11, tcf7l2, slc30a8, hhex, cdkn2a, IGF2BP2, and cdkal1 on the risk of type 2 diabetes in 5,164 indians
2068 - 2074.
genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism
1440 - 1444.
association analysis of variation in/near fto, cdkal1, slc30a8, hhex, ext2, IGF2BP2, loc387761, and cdkn2b with type 2 diabetes and related quantitative traits in pima indians
478 - 488.