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Human Endothelial lipase Recombinant

LIPG

accession:  Q9Y5X9
   Size A     5ug   $ 160
   Size B      20ug  $480
   Size C      100ug  $ 1950
Domain  : 
Gene  :  RSPO1
Catalog no. :  RKQ9Y5X9

 

Source:

Optimized DNA sequence  encoding peptidase domain of Human Endothelial lipase(SER21-PRO500) including a C-terminal His tag was expressed in HEK293 cells.


 
Molecular weight:

Recombinant human Endothelial lipase is a protein consisting of 487 amino acid residue subunits,due to glycosylation migrates as an approximately 60kDa protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human Endothelial lipase is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant Endothelial lipase can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

Endothelial lipase

Endothelial lipase is a member of the triglyceride lipase family, which includes lipoprotein lipase and hepatic lipase. Endothelial lipase is principally a phospholipase, with nominal triglyceride lipase activity. Endothelial lipase is synthesized principally by ECs15 and hydrolyzes HDL much more efficiently than other lipoproteins. Plasma HDL levels are increased in Endothelial lipase knockout (EL−/−) mice and are decreased in EL transgenic mice.Furthermore, the N396S variant in the human Endothelial lipase gene (LIPG) shows reduced lipase activity and is associated with elevated HDL-C levels

Related Publications:
interleukin 6 stimulates endothelial binding and transport of high-density lipoprotein through induction of Endothelial lipase
Arterioscler Thromb Vasc Biol, Dec 2013; 33: 2699 - 2706.
furin is the primary in vivo convertase of angiopoietin-like 3 and Endothelial lipase in hepatocytes
J. Biol. Chem., Sep 2013; 288: 26410 - 26418.
Endothelial lipase is a critical determinant of high-density lipoprotein–stimulated sphingosine 1-phosphate–dependent signaling in vascular endothelium
Arterioscler Thromb Vasc Biol, Aug 2013; 33: 1788 - 1794.
gw24-e1009 lack of association of a common polymorphism of the Endothelial lipase gene with early onset coronary artery disease in a chinese han population
Heart, Aug 2013; 99: A3.
Endothelial lipase modulates pressure overload–induced heart failure through alternative pathway for fatty acid uptake
Hypertension, May 2013; 61: 1002 - 1007.




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Antibodies:
Purified Polyclonal
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product_icon_8.jpg Human Endothelial lipase Recombinant
 
 
 
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