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Mouse Lipocalin-2 Recombinant

NGAL

accession:  P11672
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  : 
Gene  :  NGAL
Catalog no. :  RKP11672

 

Source:

Optimized DNA sequence  encoding  extracellular domain of Mouse Neutrophil gelatinase-associated lipocalin-NGAL  (GLN20-ASP200 ) including a C-terminal His tag was expressed in HEK293 cells.


 
Molecular weight:

Recombinant Mouse NGAL is a protein consisting of 185 amino acid residue subunits,due to glycosylation migrates as an approximately 25kDa protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 
Biological Activity:
The activity was tested by the ability to bind Iron dihydroxybenzoic acid and was measured to be > 1.5uM .
 
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Mouse Lipocalin-2 is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant NGAL can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

Lipocalin-2

Neutrophil gelatinase- associated lipocalin (NGAL), a 25 kDa amino acid protein, is a member of the lipocalin family largely expressed in activated neutrophils and tubular epithelial cells in response to inflammation . NGAL plays an important role in innate immunity. Accumulating evidence also has established both urinary and plasma NGAL levels as predictive biomarkers for acute kidney injury (AKI) and its outcomes in varied groups of patients including pediatric and adult populations, critically ill patients and contrast- induced nephropathy . NGAL may originate from both renal and extra-renal sites

Related Publications:
interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis
Infect. Immun., Mar 2014; 82: 1030 - 1035.
muc4-mediated regulation of acute phase protein lipocalin 2 through her2/akt/nf-b signaling in pancreatic cancer
Clin. Cancer Res., Feb 2014; 20: 688 - 700.
the induction of Lipocalin-2 expression in vivo and in vitro
J. Biol. Chem., Jan 2014; 10.1074/jbc.M113.532234.
the bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west nile virus encephalitis
J. Virol., Jan 2014; 88: 679 - 689.
lipocalin 2 induces the epithelial–mesenchymal transition in stressed endometrial epithelial cells: possible correlation with endometriosis development in a mouse model
Reproduction, Dec 2013; 147: 179 - 187.




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Antibodies:
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