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Human PD-L1 (B7-H1) Recombinant


accession:  Q9NZQ7
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  : 
Gene  :  PDCD1
Catalog no. :  RKQ9NZQ7



Optimized DNA sequence  encoding  extracellular domain of Human Programmed Death Ligand 1 ,PD-L1, (PHE19 - ARG238) including a C-terminal His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant human PD-L1 (B7-H1) is a protein consisting of 225 amino acid residue subunits,due to glycosylation migrates as an approximately 40kDa protein on reduced SDS-PAGE.

>95%, as determined by SDS-PAGE and HPLC
Biological Activity:
The activity was tested by the ability of immobilized recombinant Human PD-L1  to bind recombinant human PD1 within a linear range of 1-10ug/ml in ELISA.
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant Human PD-L1 is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

Recombinant  B7-H1 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.



The PD-L1, also called B7 homologue 1, is a B7 family protein. It mediates immune tolerance by binding to the PD-1 on activated T cells. PD-1 has two ligands, PD-L1 (B7-H1 or CD274) and PD-L2 (B7-DC or CD273). PD-L2 expression is restricted to activated dendritic cells (DC) and macrophages, whereas PD-L1 is constitutively expressed on a wide variety of cells. Furthermore, PD-L1 expression on cells including APC is up- regulated after stimulation with IFN-γ and toll-like receptor ligands .

Related Publications:
negative regulation by PD-L1 during drug-specific priming of il-22–secreting t cells and the influence of pd-1 on effector t cell function
J. Immunol., Feb 2014; 10.4049/jimmunol.1302720.
PD-L1 expression in primary clear cell renal cell carcinomas (ccrccs) and their metastases.
ASCO Meeting Abstracts, Feb 2014; 32: 467.
PD-L1 expression in non-clear cell renal cell carcinoma.
ASCO Meeting Abstracts, Feb 2014; 32: 424.
PD-L1 limits the mucosal cd8+ t cell response to chlamydia trachomatis
J. Immunol., Feb 2014; 192: 1079 - 1090.
PD-L1 expression in triple negative breast cancer
Cancer Immunology, Jan 2014; 10.1158/2326-6066.CIR-13-0127.

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Purified Polyclonal
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