Cart contains    items
SEARCH

  |
  |  
  |  
  |  
  |  
  |  
 
Browse by molecule: [A]  [B]  [C]  [D]  [E]  [F]  [G]  [H]  [I]  [J]  [K]  [L]  [M]  [N]  [O]  [P]  [Q]  [R]  [S]  [T]  [U]  [V]  [W]  [X]  [Y]  [Z]  

Human Sclerostin Recombinant

SOST

accession:  Q9BQB4
   Size A     20ug   $ 160
   Size B      100ug  $680
   Size C      500ug  $ 2750
Domain  : 
Gene  :  Sclerostin
Catalog no. :  RKQ9BQB4

 

Source:

Optimized DNA sequence  encoding  extracellular domain of Human Sclerostin (GLN24 - TYR213) including a N-terminal His tag was expressed in HEK293 cells. 


 
Molecular weight:

Recombinant SOST is a  protein consisting of 195 amino acid residue subunits,  due to glycosylation migrates as an approximately 35kDa protein on SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human Sclerostin is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant Sclerostin can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

sclerostin

Sclerostin is an endogenous antagonist secreted almost always exclusively by osteocytes, and it has been extensively studied as a major regulator of canonical Wnt pathway in bone metabolism . Sclerostin, an osteocyte- derived, secreted, cystine- knot protein inhibits bone formation by interacting with and altering the activity of bone morphogenetic proteins (BMPs), low-density lipoprotein-receptor–related protein 5 (LRP 5/6), cysteine-rich protein 61, the receptor tyrosine kinase v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (erb B3), among other proteins.Inactivating mutations in the human sclerostin gene (SOST) are associated with sclerosteosis or van Buchem disease both of which are characterized by progressive overgrowth and sclerosis of the axial and appendicular skeleton and an increase in bone mineral density

Related Publications:
effect of supplemental vitamin d and calcium on serum sclerostin levels
Eur. J. Endocrinol., Jan 2014; 10.1530/EJE-13-0862.
the relationship between inhibitors of the wnt signalling pathway (sclerostin and dickkopf-1) and carotid intima-media thickness in postmenopausal women with type 2 diabetes mellitus
Diabetes and Vascular Disease Research, Jan 2014; 11: 48 - 52.
sclerostin: another bone-related protein related to all-cause mortality in haemodialysis?
Nephrol. Dial. Transplant., Dec 2013; 28: 3024 - 3030.
role of sclerostin in bone and cartilage and its potential as a therapeutic target in bone diseases
Therapeutic Advances in Musculoskeletal Diseases, Nov 2013; 10.1177/1759720X13510479.
sclerostin inhibition reverses skeletal fragility in an lrp5-deficient mouse model of oppg syndrome
Science Translational Medicine, Nov 2013; 5: 211ra158.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
Related Products:
product_icon_8.jpg Human Sclerostin Recombinant, Biotinylated
product_icon_8.jpg Human Sclerostin Recombinant
 
 
 
Item name Size Quantity Price(USD) Remove
checkout
Cart Total $