Cart contains    items

Browse by molecule: [A]  [B]  [C]  [D]  [E]  [F]  [G]  [H]  [I]  [J]  [K]  [L]  [M]  [N]  [O]  [P]  [Q]  [R]  [S]  [T]  [U]  [V]  [W]  [X]  [Y]  [Z]  

Mouse IL-13 alpha 1 receptor Recombinant (IL13RA1)

IL-13 R

accession:  O09030
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  : 
Gene  :  IL13RA1
Catalog no. :  RKO09030

Optimized DNA sequence  encoding extracellular domain of mouse IL-13 receptor alpha 1  including a C terminal His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant mouse IL-13 receptor alpha 1 is a hmonomer protein consisting of 325 amino acid residue subunits,  due to glycosylation migrates as an approximately 50kDa protein on SDS-PAGE.

>98%, as determined by SDS-PAGE and HPLC

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant mouse IL-13 receptor alpha 1  is supplied as lyophilized 0.2 μm filtered PBS solution,  pH7.2 .

Recombinant mouse IL13RA1, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.



The biological activity of IL-13 is regulated via the IL-13R type I and type II . The type I receptor is a heterodimer of the IL-4R α chain (IL-4Rα) and IL-13Rα1, and ligand-receptor interactions induce phosphorylation of the IL- 4Rα and subsequent activation of the signal transducers and activators of transcription (STAT)-6 signaling pathway. This pathway appears to be the primary pathway for IL-13- induced signaling in nonhematopoietic cells. The type II receptor is composed of IL-13Rα1 and IL-13Rα2 . IL-13Rα2 binds IL-13 with high affinity and is proposed to act as a decoy receptor that limits the activity of IL-13. Consistent with this, mice deficient in IL-13Rα2 demonstrate exaggerated IL- 13-induced pathologies . IL- 13Rα2 possesses a short cytoplasmic tail and is without signal motifs; however, there have been a number of reports to suggest IL-13 signals through this chain, possibly via a STAT6- independent, AP-1-dependent manner to induce activation of the Tgfβ1 promoter via the IL-13 type II receptor.

Related Publications:
IL-13R2 has a protective role in a mouse model of cutaneous inflammation
J. Immunol., Dec 2010; 185: 6802 - 6808.
IL-13R2 membrane and soluble isoforms differ in humans and mice
J. Immunol., Dec 2009; 183: 7870 - 7876.
tuning sensitivity to il-4 and il-13: differential expression of il-4r, IL-13R1, and c regulates relative cytokine sensitivity
J. Exp. Med., Oct 2008; 205: 2595 - 2608.
novel role of il-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model
J. Immunol., Oct 2008; 181: 4656 - 4665.
targeting IL-13R2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated pseudomonas exotoxin
Mol. Cancer Ther., Jun 2008; 7: 1579 - 1587.

by class:
Growth factors
CD markers
Viral Antigens
by species:
Purified Polyclonal
Related Products:
product_icon_8.jpg Human IL-13 alpha 2 receptor Recombinant (IL13RA2)
product_icon_8.jpg Human IL-13 alpha 1 receptor Recombinant (IL13RA1)
product_icon_8.jpg Human IL-13 alpha 1 receptor Fc tag Recombinant (IL13RA1)
product_icon_8.jpg Mouse IL-13 alpha 1 receptor Recombinant (IL13RA1)
product_icon_8.jpg Mouse IL-13 alpha 2 receptor Recombinant (IL13RA2)
Item name Size Quantity Price(USD) Remove
Cart Total $