Cart contains    items
SEARCH

  |
  |  
  |  
  |  
  |  
  |  
 
Browse by molecule: [A]  [B]  [C]  [D]  [E]  [F]  [G]  [H]  [I]  [J]  [K]  [L]  [M]  [N]  [O]  [P]  [Q]  [R]  [S]  [T]  [U]  [V]  [W]  [X]  [Y]  [Z]  

Human PDGFR beta Recombinant

PDGF-R

accession:  P09619
   Size A     50ug   $ 160
   Size B      200ug  $550
   Size C      1mg  $ 1950
Domain  :  Ig-like C2
Gene  :  PDGF Receptor beta
Catalog no. :  RKP09619

Source:
Optimized DNA sequence  encoding Human extracellular domain of human PDGFR beta ncluding a C-terminal 6His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant PDGF-R beta is a monomer protein consisting of 510 amino acid residue subunits, due to glycosylation migrates as an approximately 100 kDa protein on SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant PDGFR beta  is supplied as a 0.2 μm filtered PBS solution,  pH7.2.

              
Storage:
Recombinant PDGFRb , as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

PDGFR beta

The PDGFR/PDGF system includes two receptors (PDGFRA and PDGFRB) and four ligands (PDGFA, PDGFB, PDGFC, and PDGFD. Ligand binding induces receptor dimerization, enabling autophosphorylation of specific tyrosine residues and subsequent recruitment of a variety of signal transduction molecules . PDGFR regulates normal cellular growth and differentiation , and expression of activated PDGFR promotes oncogenic transformation , suggesting that activating mutations or gene rearrangements could play a role in human tumorigenesis. Numerous in vitro and in vivo studies showed that inhibition of PDGFRA signaling disrupts cancer cell survival in the subset of GISTs with activating PDGFRA mutations.

Related Publications:
hydrophobic matching controls the tilt and stability of the dimeric platelet-derived growth factor receptor (pdgfr) β transmembrane segment
J. Biol. Chem., Jul 2012; 287: 26178 - 26186.
pdgfrβ expression and function in fibroblasts derived from pluripotent cells is linked to dna demethylation
J. Cell Sci., May 2012; 125: 2276 - 2287.
pdgf-induced migration of vascular smooth muscle cells is inhibited by heme oxygenase-1 via vegfr2 upregulation and subsequent assembly of inactive vegfr2/pdgfrβ heterodimers
Arterioscler Thromb Vasc Biol, May 2012; 32: 1289 - 1298.
a viable mouse pdgfr-beta mutant exhibits cns-restricted pericyte deficiency and blood brain barrier defects
Invest. Ophthalmol. Vis. Sci., Mar 2012; 53: 2558.
the leukemia-associated fusion protein tel-platelet-derived growth factor receptor β (tel-pdgfrβ) inhibits transcriptional repression of ptpn13 gene by interferon consensus sequence binding protein (icsbp)
J. Biol. Chem., Mar 2012; 287: 8110 - 8125.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
Related Products:
product_icon_8.jpg Human PDGFR alpha Recombinant
product_icon_8.jpg Human PDGFR beta Recombinant
product_icon_8.jpg Rat PDGFR beta Recombinant
 
 
 
Item name Size Quantity Price(USD) Remove
checkout
Cart Total $