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Mouse Interleukin-17 Recombinant

IL-17

accession:  Q62386
   Size A     5ug   $ 70
   Size B      25ug  $160
   Size C      1mg  $ 2700
Domain  :  four helix cytokine core
Gene  :  IL17A
Catalog no. :  RKQ62386
Source:
Optimized DNA sequence encoding Mouse Interleukin-17A mature chain was expressed in Escherichia Coli.

 
Molecular weight:

Native Mouse Interleukin17A, generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 16kDa.

Recombinant Mouse IL-17A is a disulfide-linked monodimeric protein consisting of 137 amino acid residue subunits, and migrates as an approximately 16kDa protein under reducing conditions in SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
The activity was measured by the ability to bind Human IL17RA in a functional ELISA assay with a linear range of 10-500 ng/ml.

 
 
(*)Complete precursor sequence shown, expressed chain highlighted
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Mouse Interleukin-17 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

 

IL-17a

Interleukin-17 (IL-17 or IL- 17A) is the founder member of the IL-17 cytokine family, which shares 50% homology with IL-17F. IL-17 cytokines are produced by T- helper (TH)17 cells, γδ T cells, and other immune cells. IL-17A and IL-17F form homodimers and heterodimers as functional ligands. IL-17 cytokines bind to 2 receptors, IL-17RA and IL-17RC. IL-17RC forms a receptor heterodimer with IL-17RA. The receptor heterodimer is preferred by IL-17 ligands , thus, either IL-17RA knockout (KO) or IL- 17RC KO completely abolishes IL-17 signaling . IL-17A and IL-17F are key proinflammatory cytokines involved in many inflammatory and autoimmune diseases.

Related Publications:
the innate immune response to uropathogenic escherichia coli involves IL-17a in a murine model of urinary tract infection
J. Immunol., Jan 2010; 10.4049/jimmunol.0902386.
characterization of IL-17a–producing cells in celiac disease mucosa
J. Immunol., Jan 2010; 10.4049/jimmunol.0901919.
enhanced production of IL-17a during zymosan-induced peritonitis in obese mice
J. Leukoc. Biol., Jan 2010; 87: 51 - 58.
IL-17a and il-17f stimulate chemokines via mapk pathways (erk1/2 and p38 but not jnk) in mouse cultured mesangial cells: synergy with tnf- and il-1
Am J Physiol Renal Physiol, Dec 2009; 10.1152/ajprenal.00198.2009.
engineering of stable bispecific antibodies targeting IL-17a and il-23
Protein Eng. Des. Sel., Dec 2009; 10.1093/protein/gzp073.




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Antibodies:
Purified Polyclonal
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