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Human TGF Beta-1 receptor 2 (TGRBR2) Recombinant

TGF beta

accession:  P37173
   Size A     10ug   $ 160
   Size B      50ug  $550
   Size C      500ug  $ 3500
Domain  :  cystine knot growth factor
Gene  :  TGFBR2
Catalog no. :  RKP37173

Source:
Optimized DNA sequence encoding Human TGF beta receptor 2 extracellular domain fused to an Fc domain was expressed in HEK293 cells

 
Molecular weight:

 

Recombinant TGFBR2/Fc  is a homodimer protein consisting of 2x383 amino acid residue subunits, due to glycosylation migrates as an approximately 66 kDa protein on SDS-PAGE.

 
Purity:
>97%, as determined by SDS-PAGE and HPLC.

 
Biological activity:

 

The ED(50) was determined by the ability to bind TGFb1 and was found to be 1-3  ug/ml in the presence of TGFb1 at a concentration of  1ng/ml.

 

Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant TGF-b1 is lyophilized from  0.2 μm filtered 100mM Glycine , 10mM NaCl, 50mM Tris , pH 7.5.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:

Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months.


Avoid repeated freeze/thaw cycles.


 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

 

TGFBR2

TGF-beta is the prototype of a protein family known as the TGF-beta superfamily. This family includes Inhibins, Activin A, MIS (Müllerian inhibiting substance), BMP (bone morphogenetic proteins), dpp (decapentaplegic) and Vg-1. Type 1 receptors and type 2 receptors have a molecular mass of 53 and 75 kDa, respectively. Signaling through the receptor requires heterodimeric complexes between both types of receptors. The type 2 receptor has been shown to bind the ligand, but it is incapable of mediating TGF- beta responses in the absence of the type 1 receptor. The type 1 receptor is expressed predominantly in hematopoietic progenitor cells. The type 2 receptor encodes a protein with an intracellular domain that functions as a serine/threonine kinase. TGF-beta is the most potent known growth inhibitor for normal and transformed epithelial cells, endothelial cells, fibroblasts, neuronal cells, lymphoid cells and other hematopoietic cell types. TGF-beta inhibits the proliferation of T- lymphocytes by down- regulating predominantly IL- 2 mediated proliferative signals. It also inhibits the growth of natural killer cells in vivo and deactivates macrophages. TGF-beta blocks the antitumor activity mediated in vivo by IL-2 and transferred lymphokine- activated or tumor infiltrating lymphocytes.

Related Publications:
cell cycle arrest by tgf-1 enhances rsv replication in lung epithelial cells
J. Virol., Sep 2009; 10.1128/JVI.00806-09.
cutting edge: tgf-β1 and il-15 induce foxp3+ regulatory t cells in the presence of antigen stimulation
J. Immunol., Sep 2009; 183: 3574 - 3577.
nuclear factor i-c links pdgf and tgf-1 signaling to skin wound healing progression
Mol. Cell. Biol., Sep 2009; 10.1128/MCB.01921-08.
mesenchymal stem cells produce wnt isoforms and tgf1 that mediate proliferation and pro-collagen expression by lung fibroblasts
Am J Physiol Lung Cell Mol Physiol, Sep 2009; 10.1152/ajplung.90347.2008.
mechanical forces and tgfβ1 reduce podocyte adhesion through 3β1 integrin downregulation
Nephrol. Dial. Transplant., Sep 2009; 24: 2645 - 2655.




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