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Human IL-11 receptor alpha Recombinant

IL-11

accession:  Q14626
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  :  Extracellular
Gene  :  IL11RA
Catalog no. :  RKQ14626
Source:
DNA sequence encoding extracellular domain of human IL-11RA  fused to a C-terminal polyHis tag was expressed in HEK cells.

 
Molecular weight:

Recombinant Human Interleukin-11RA  is a monomer consisting of 351 amino acid residue subunits, and migrates as an approximately 46 kDa protein under reducing conditions in SDS-PAGE.

 
Purity:
>97%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
The activity was determined by its ability to bind Human IL-6ST in functional ELISA .

 
Protein Sequence:
      10         20         30         40         50         60 
MSSSCSGLSR VLVAVATALV SASSPCPQAW GPPGVQYGQP GRSVKLCCPG VTAGDPVSWF 

        70         80         90        100        110        120 
RDGEPKLLQG PDSGLGHELV LAQADSTDEG TYICQTLDGA LGGTVTLQLG YPPARPVVSC 

       130        140        150        160        170        180 
QAADYENFSC TWSPSQISGL PTRYLTSYRK KTVLGADSQR RSPSTGPWPC PQDPLGAARC 

       190        200        210        220        230        240 
VVHGAEFWSQ YRINVTEVNP LGASTRLLDV SLQSILRPDP PQGLRVESVP GYPRRLRASW 

       250        260        270        280        290        300 
TYPASWPCQP HFLLKFRLQY RPAQHPAWST VEPAGLEEVI TDAVAGLPHA VRVSARDFLD 

       310        320        330        340        350        360 
AGTWSTWSPE AWGTPSTGTI PKEIPAWGQL HTQPEVEPQV DSPAPPRPSL QPHPRLLDHR 

       370        380        390        400        410        420 
DSVEQVAVLA SLGILSFLGL VAGALALGLW LRLRRGGKDG SPKPGFLASV IPVDRRPGAP 


NL 
(*)Complete precursor sequence shown, expressed chain highlighted
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Interleukin-11receptor alpha was lyophilized from a 0.2 μm filtered PBS solution pH 7.4.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

IL-11 receptor alpha

Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.

Related Publications:
il-11 receptor in the pathogenesis of il-13-induced inflammation and remodeling
J. Immunol., Feb 2005; 174: 2305 - 2313.
recombinant soluble interleukin-11 (il-11) receptor -chain can act as an il-11 antagonist
Blood, Dec 1997; 90: 4403 - 4412.




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