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Human IL-13 alpha 2 receptor Recombinant (IL13RA2)

IL-13 R

accession:  Q14627
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  : 
Gene  :  IL13RA2
Catalog no. :  RKQ14627

Source:
Optimized DNA sequence  encoding extracellular domain of human IL-13 receptor alpha2  including an IgG1 human Fc region was expressed in HEK293 cells.

 
Molecular weight:

Recombinant IL-13RA2 is a homodimer protein consisting of 563 amino acid residue subunits,  due to glycosylation migrates as an approximately 130kDa protein on SDS-PAGE.


 
Purity:
>98%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
Measured by its ability to bind recombinant human Interleukin-13 at a concentration range of 0.3-8 ng/ml .

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant IL-13 receptor alpha 2  is supplied as lyophilized 0.2 μm filtered 50mM Tris ,100mM glycine solution,  pH7.5  and 5% trehalose.

              
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. It is recommended to add 0.1% HSA or BSA for long term storage.

              
Storage:
Recombinant IL13RA2, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

IL-13R

The biological activity of IL-13 is regulated via the IL-13R type I and type II . The type I receptor is a heterodimer of the IL-4R α chain (IL-4Rα) and IL-13Rα1, and ligand-receptor interactions induce phosphorylation of the IL- 4Rα and subsequent activation of the signal transducers and activators of transcription (STAT)-6 signaling pathway. This pathway appears to be the primary pathway for IL-13- induced signaling in nonhematopoietic cells. The type II receptor is composed of IL-13Rα1 and IL-13Rα2 . IL-13Rα2 binds IL-13 with high affinity and is proposed to act as a decoy receptor that limits the activity of IL-13. Consistent with this, mice deficient in IL-13Rα2 demonstrate exaggerated IL- 13-induced pathologies . IL- 13Rα2 possesses a short cytoplasmic tail and is without signal motifs; however, there have been a number of reports to suggest IL-13 signals through this chain, possibly via a STAT6- independent, AP-1-dependent manner to induce activation of the Tgfβ1 promoter via the IL-13 type II receptor.

Related Publications:
IL-13R2 has a protective role in a mouse model of cutaneous inflammation
J. Immunol., Dec 2010; 185: 6802 - 6808.
IL-13R2 membrane and soluble isoforms differ in humans and mice
J. Immunol., Dec 2009; 183: 7870 - 7876.
tuning sensitivity to il-4 and il-13: differential expression of il-4r, IL-13R1, and c regulates relative cytokine sensitivity
J. Exp. Med., Oct 2008; 205: 2595 - 2608.
novel role of il-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model
J. Immunol., Oct 2008; 181: 4656 - 4665.
targeting IL-13R2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated pseudomonas exotoxin
Mol. Cancer Ther., Jun 2008; 7: 1579 - 1587.




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Antibodies:
Purified Polyclonal
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