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Human EPO receptor Recombinant (EPOR)

EPOR

accession:  P19235
   Size A     20ug   $ 160
   Size B      100ug  $550
   Size C      500ug  $ 2150
Domain  : 
Gene  :  EPOR
Catalog no. :  RKP19235

Source:
Optimized DNA sequence  encoding extracellular domain of human erythropoietin receptor including a C-terminal His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant EPO receptor is a monomer protein consisting of 237 amino acid residue subunits,  due to glycosylation migrates as an approximately 35 kDa protein on SDS-PAGE.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant EPO receptor  is supplied as a 0.2 μm filtered PBS solution,  pH7.2 .

              
Storage:
Recombinant EPOR, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

EPOR

Erythropoietin (Epo) binds to the Epo receptor (EpoR) on the surface of erythroid precursor cells, stimulating their proliferation, survival, and differentiation into mature red cells. The EPO receptor is a member of a family of cytokine receptors that includes receptors for prolactin, growth hormone, interleukins 2-7, granulocyte macrophage colony-stimulating factor, granulocyte colony- stimulating factor, leukemia inhibitory factor, thrompopoietin ligand, and ciliary neurotrophic factor . This family is characterized by regions of similarity in their extracellular and intracellular domains. The family is also characterized by a lack of an identifiable protein tyrosine kinase domain in their intracellular region. Activation of the receptors by ligand binding induces a cascade of signaling events including phosphorylation of the EPO receptor, activation of the JAK-STAT pathway, activation of PI3 kinase, and activation of the RAS- MAPK pathway.

Related Publications:
different expression patterns of ngb and EPOR in the cerebral cortex and hippocampus revealed distinctive therapeutic effects of intranasal delivery of neuro-epo for ischemic insults to the gerbil brain
Journal of Histochemistry & Cytochemistry, Feb 2011; 59: 214 - 227.
EPOR over-expression in tel-aml1 positive all: critical roles for dna methylation, gata-2 or micrornas?
Blood (ASH Annual Meeting Abstracts), Nov 2010; 116: 3619.
epo/EPOR signaling critically regulates maturation of the primitive erythroid lineage in the mammalian embryo
Blood (ASH Annual Meeting Abstracts), Nov 2010; 116: 813.
etv6-runx1 (tel-aml1) deregulates the erythropoietin receptor (EPOR) and promotes cell survival.
Blood (ASH Annual Meeting Abstracts), Nov 2010; 116: 3641.
absence of functional EPOR expression in human tumor cell lines
Blood, May 2010; 115: 4254 - 4263.




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Antibodies:
Purified Polyclonal
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