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Rabbit anti TGF-alpha Polyclonal

TGF alpha

accession:  P01135
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA01135
Applications:
Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
 
TGF alpha IHC

Immunohistochemical analysis of TGF alpha expression in FFPE rat colon tissue.  

Cat#RPA01135 was used as primary antibody dilution 1:500, DAB chromogen substrate.

 
Source:
Polyclonal TGF-alpha antibody was produced from sera of rabbits  immunized with synthetic protein containing TGF-alpha antigenic determinants. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

TGF-alpha

TGF-alpha is produced by a number of human carcinomas and cell lines transformed by viral and cellular Oncogene.The production of TGF-alpha in pituitary cells in inhibited by TGF-beta. TGF-alpha is produced by keratinocytes, macrophages, hepatocytes, platelets. Its synthesis is stimulated by infection with viruses. In mammary tissue its synthesis is induced by estrogens. The protein has a length of 50 amino acids. It is not related to TGF-beta. The factor is obtained by proteolytic processing of a transmembrane precursor protein of 160 amino acids. Membrane-associated elastase-like serine proteases have been implicated in the processing of the pro-TGF-alpha form. Rat and murine TGF-alpha are almost identical with the human factor. TGF-alpha is related closely to EGF and TGF-alpha is therefore sometimes called EGF-like transforming growth factor. The biological activities of these two growth factors are very similar and both bind to the same receptor. The transmembrane precursor of TGF-alpha can bind to EGF receptors on near-by cells. This enables it to establish specific cell-to-cell contacts and to elicit developmentally important responses in neighboring cells.

Related Publications:
serum-transforming growth factor- (tgf-) and response to lapatinib plus capecitabine in her2-positive (her2+) metastatic breast cancer (mbc).
ASCO Meeting Abstracts, May 2010; 28: 1102.
post-infarct intramyocardial injection of mesenchymal stem cells pretreated with tgf- improves acute myocardial function
Am J Physiol Regulatory Integrative Comp Physiol, May 2010; 10.1152/ajpregu.00084.2010.
transforming growth factor- (tgf-) enhances corneal epithelial cell migration by promoting egfr recycling
Invest. Ophthalmol. Vis. Sci., Feb 2010; 10.1167/iovs.09-4386.
g protein-coupled receptor 30 expression is up-regulated by egf and tgf in estrogen receptor -positive cancer cells
Mol. Endocrinol., Nov 2009; 23: 1815 - 1826.
adam17 upregulation in human renal disease: a role in modulating tgf- availability?
Am J Physiol Renal Physiol, Sep 2009; 297: F781 - F790.




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by species:
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mouse
Rat
Antibodies:
Purified Polyclonal
Related Products:
product_icon_7.jpg Rabbit anti TGF-alpha Polyclonal
product_icon_8.jpg Human TGF alpha Recombinant
 
 
 
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