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Rabbit anti MCP-1 Polyclonal

MCP-1

accession:  P13500
   Size A     100ug   $ 290
   Size B      200ug  $390
   Size C      500ug  $ 590
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA13500
Applications:
Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
 
MCP-1 IHC

Immunohistochemical analysis of MCP-1 expression in paraffin fixed obese mouse proximal tubule tissue.

Cat# RPA13500 was used as primary antibody, dilution 1:400.

 
Source:
Polyclonal MCP-1(CCL2) antibody was produced from sera of rabbits  immunized with synthetic protein containing MCP-1  antigenic determinants. 
 
Species reactivity:
Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein A affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

mcp-1

MCP-1 belongs to the family of chemotactic cytokines.MCP-1 is expressed by monocytes, vascular endothelial cells, smooth muscle cells, glomerular mesangial cell, osteoblastic cells. MCP-1 has been shown to exhibit biological activities other than Chemotaxis. It can induce the proliferation and activation of killer cells known as CHAK. Elevated levels of MCP-1 are observed in atherosclerotic plaques that are rich in macrophages. The factor activates the tumoricidal activity of monocytes and macrophages in vivo. It regulates the expression of cell surface antigens (CD11c, CD11b) and the expression of cytokines (IL1, IL6). MCP-1 is a potent activator of human basophils, inducing degranulation and the release of histamines. In basophils activated by IL3, IL5 or GM-CSF MCP-1 enhances the synthesis of leukotriene C4.

Related Publications:
rationally evolving mcp-1/ccl2 into a decoy protein with potent anti-inflammatory activity in vivo
J. Biol. Chem., Mar 2010; 285: 8782 - 8792.
association of the mcp-1 -2518 a/g polymorphism and no association of its receptor ccr2 -64 v/i polymorphism with lupus nephritis
J Rheumatol, Mar 2010; 10.3899/jrheum.090681.
mcp-1/ccl2 modifies axon properties in a pmp22-overexpressing mouse model for charcot-marie-tooth 1a neuropathy
Am. J. Pathol., Mar 2010; 176: 1390 - 1399.
critical protective role for mcp-1 in pneumonic burkholderia mallei infection
J. Immunol., Feb 2010; 184: 1445 - 1454.
thioredoxin 1 downregulates mcp-1 secretion in human endothelial cells by suppressing nuclear translocation of activator protein 1 and redox factor-1
Am J Physiol Cell Physiol, Dec 2009; 10.1152/ajpcell.00223.2009.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
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product_icon_8.jpg Mouse MCP-1(CCL2) Recombinant
 
 
 
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