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Human TARC (CCL17) Recombinant

TARC

accession:  Q92583
   Size A     5ug   $ 70
   Size B      20ug  $160
   Size C      1mg  $ 2700
Domain  :  IL8
Gene  :  CCL17
Catalog no. :  RKQ92583
Source:
Optimized DNA sequence encoding Human TARC (CCL17) mature chain was expressed in Escherichia Coli.

 
Molecular weight:

Human CCL-17, generated by the proteolytic removal of the signal peptide
and propeptide and has a calculated molecular mass of approximately 8kDa.

Recombinant TARC is a disulfide-linked monomeric protein consisting of 72 amino acid residue subunits and migrates as an approximately 8 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.


 
Purity:
>98%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
Determined by its ability to chemoattract human T cells using a concentration range of 2.0-40.0 ng/ml.

 
Protein Sequence:
        10         20         30         40         50         60 
MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW YQTSEDCSRD 

        70         80         90 
AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS 
(*)Complete precursor sequence shown, expressed chain highlighted
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant TARC was lyophilized from a 0.2 μm filtered 20mM PB,100mM NaCl solution pH 7.5.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CCL17

Thymus and activation- regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells. TARC functions as a selective chemoattractant for T cells that express a class of receptors binding TARC with high affinity and specificity.The chemokine TARC is a ligand for the chemokine receptor CCR4 expressed on T helper (Th)2- type CD4 T cells.

Related Publications:
il-12 produced by dendritic cells augments cd8+ t cell activation through the production of the chemokines ccl1 and CCL17
J. Immunol., Dec 2008; 181: 8576 - 8584.
clinical significance of serum tarc/CCL17 in atll patients: high tarc/CCL17 level is a significant unfavorable prognostic factor
Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 2821.
respiratory syncytial virus synergizes with th2 cytokines to induce optimal levels of tarc/CCL17
J. Immunol., Aug 2007; 179: 1648 - 1658.
circulating thymus- and activation-regulated chemokine/CCL17 is a useful biomarker for discriminating acute eosinophilic pneumonia from other causes of acute lung injury
Chest, Jun 2007; 131: 1726 - 1734.
evidence that phospholipase c-dependent, calcium-independent mechanisms are required for directional migration of t lymphocytes in response to the ccr4 ligands CCL17 and ccl22
J. Leukoc. Biol., Jun 2006; 79: 1369 - 1380.




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product_icon_8.jpg Human TARC (CCL17) Recombinant
 
 
 
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