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Human PDGFR alpha Recombinant


accession:  P16234
   Size A     20ug   $ 160
   Size B      100ug  $550
   Size C      500ug  $ 1950
Domain  :  Ig-like C2
Gene  :  PDGF Receptor alpha
Catalog no. :  RKP16234

Optimized DNA sequence  encoding Human extracellular domain of human PDGF-R alpha including a C-terminal 6His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant PDGFRa is a monomer protein consisting of 510 amino acid residue subunits, due to glycosylation migrates as an approximately 90-100 kDa protein on SDS-PAGE.

>95%, as determined by SDS-PAGE and HPLC

Biological Activity:
The Activity was measured by the ability to bind human PDGFC-Fc in functional ELISA.

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant CD140a  is supplied as a 0.2 μm filtered PBS solution,  pH7.2.

Recombinant CD140a, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.


PDGFR alpha

The PDGFR/PDGF system includes two receptors (PDGFRA and PDGFRB) and four ligands (PDGFA, PDGFB, PDGFC, and PDGFD. Ligand binding induces receptor dimerization, enabling autophosphorylation of specific tyrosine residues and subsequent recruitment of a variety of signal transduction molecules . PDGFR regulates normal cellular growth and differentiation , and expression of activated PDGFR promotes oncogenic transformation , suggesting that activating mutations or gene rearrangements could play a role in human tumorigenesis. Numerous in vitro and in vivo studies showed that inhibition of PDGFRA signaling disrupts cancer cell survival in the subset of GISTs with activating PDGFRA mutations.

Related Publications:
pdgfrα signaling in the primary cilium regulates nhe1-dependent fibroblast migration via coordinated differential activity of mek1/2-erk1/2-p90rsk and akt signaling pathways
J. Cell Sci., Dec 2012; 10.1242/jcs.116426.
functional expression of sk channels in murine detrusor pdgfrα+ cells
J. Physiol., Dec 2012; 10.1113/jphysiol.2012.241505.
pdgfrα and cd51 mark human nestin+ sphere-forming mesenchymal stem cells capable of robust hematopoietic stem cell expansion
Blood (ASH Annual Meeting Abstracts), Nov 2012; 120: 505.
candidate human primary mesenchymal stem/progenitor cells are highly enriched in linneg/cd45neg/cd271pos/pdgfrαneg bone marrow cells
Blood (ASH Annual Meeting Abstracts), Nov 2012; 120: 3460.
stromal platelet-derived growth factor receptor α (pdgfrα) provides a therapeutic target independent of tumor cell pdgfrα expression in lung cancer xenografts
Mol. Cancer Ther., Nov 2012; 11: 2473 - 2482.

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Purified Polyclonal
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