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Human LIFR Recombinant (CD118)


accession:  P42702
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  :  Ig-like C2
Gene  :  LIFR
Catalog no. :  RKP42702

Optimized DNA sequence  encoding Human extracellular domain of human LIFR (CD118) including a C-terminal 6His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant LIFR (CD118) is a monomer protein consisting of 794 amino acid residue subunits,  due to glycosylation migrates as an approximately 125-135 kDa protein on SDS-PAGE.

>90%, as determined by SDS-PAGE and HPLC

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant CD118 is supplied as a 0.2 μm filtered PBS solution,  pH7.2 .

Recombinant CD118, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.


LIF receptor

LIF acts on its target cells via the activation of the LIF-receptor (LIFR) complex. The LIFR complex requires heterodimerisation of the two low affinity components LIFR and glycoprotein 130 (gp130), where combination transforms a low-affinity binding complex into a high- affinity binding site. Activation of the LIFR complex can trigger several signal transduction paIn LIF-induced heterodimerization with the LIFR, only the CBM of gp130 contacts LIF . The LIFR contributes mainly with its Ig-like domain to LIF binding .

Related Publications:
determining the lif-sensitive period for implantation using a lif-receptor antagonist
Reproduction, Nov 2009; 138: 827 - 836.
loss of myocardial LIF receptor in experimental heart failure reduces cardiotrophin-1 cytoprotection. a role for neurohumoral agonists?
Cardiovasc Res, Aug 2007; 75: 536 - 545.
an unusual cytokine:ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (lif) in complex with the LIF receptor
PNAS, Jul 2007; 104: 12737 - 12742.
an in vitro and in vivo evidence that downregulation of leukemia inhibitory factor (lif) receptor (lif-r) decreases the metastatic potential of human rhabdomyosarcoma (rms) cells.
Blood (ASH Annual Meeting Abstracts), Nov 2006; 108: 2561.
evidence for heterodimeric association of leukemia inhibitory factor (lif) receptor and gp130 in the mouse uterus for lif signaling during blastocyst implantation
Reproduction, Feb 2006; 131: 341 - 349.

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Purified Polyclonal
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product_icon_8.jpg Human LIFR Recombinant (CD118)
product_icon_8.jpg Mouse LIFR Recombinant (CD118)
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