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Human LIFR Recombinant (CD118)

LIF-R

accession:  P42702
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  :  Ig-like C2
Gene  :  LIFR
Catalog no. :  RKP42702

Source:
Optimized DNA sequence  encoding Human extracellular domain of human LIFR (CD118) including a C-terminal 6His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant LIFR (CD118) is a monomer protein consisting of 794 amino acid residue subunits,  due to glycosylation migrates as an approximately 125-135 kDa protein on SDS-PAGE.


 
Purity:
>90%, as determined by SDS-PAGE and HPLC

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant CD118 is supplied as a 0.2 μm filtered PBS solution,  pH7.2 .

              
Storage:
Recombinant CD118, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

LIF receptor

LIF acts on its target cells via the activation of the LIF-receptor (LIFR) complex. The LIFR complex requires heterodimerisation of the two low affinity components LIFR and glycoprotein 130 (gp130), where combination transforms a low-affinity binding complex into a high- affinity binding site. Activation of the LIFR complex can trigger several signal transduction paIn LIF-induced heterodimerization with the LIFR, only the CBM of gp130 contacts LIF . The LIFR contributes mainly with its Ig-like domain to LIF binding .

Related Publications:
determining the lif-sensitive period for implantation using a lif-receptor antagonist
Reproduction, Nov 2009; 138: 827 - 836.
loss of myocardial LIF receptor in experimental heart failure reduces cardiotrophin-1 cytoprotection. a role for neurohumoral agonists?
Cardiovasc Res, Aug 2007; 75: 536 - 545.
an unusual cytokine:ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (lif) in complex with the LIF receptor
PNAS, Jul 2007; 104: 12737 - 12742.
an in vitro and in vivo evidence that downregulation of leukemia inhibitory factor (lif) receptor (lif-r) decreases the metastatic potential of human rhabdomyosarcoma (rms) cells.
Blood (ASH Annual Meeting Abstracts), Nov 2006; 108: 2561.
evidence for heterodimeric association of leukemia inhibitory factor (lif) receptor and gp130 in the mouse uterus for lif signaling during blastocyst implantation
Reproduction, Feb 2006; 131: 341 - 349.




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Antibodies:
Purified Polyclonal
Related Products:
product_icon_8.jpg Human LIFR Recombinant (CD118)
product_icon_8.jpg Mouse LIFR Recombinant (CD118)
 
 
 
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