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Rabbit anti FGF-10 Polyclonal

FGF-10

accession:  O15520
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA15520
Applications:
Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
 
Source:
Polyclonal FGF-10 antibody was produced from sera of rabbits  immunized with synthetic protein containing synthetic  protein containing FGF-10 antigenic determinants. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in sterile 10mM PBS pH 7.4 .
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

FGF10

FGF-10 is involved in the initial budding as well as the continuous outgrowth of vertebrate limbs, FGF10 mRNA is expressed preferentially in neurons but not in glial cells and may have a distinct role in the brain. human FGF-10 is mitogenic for fetal rat keratinizing epidermal cells but not for NIH 3T3 cells .Recombinant FGF10 induces the proliferation of human urothelial cells in vitro and induces the proliferation of transitional epithelium. FGF-10 is secreted by cultured mouse pre- adipocytes, prevention of FGF-10 signaling inhibits subsequent differentiation. The ability of embryonic fibroblasts derived from FGF-10 knock-out mice to differentiate into adipocytes is also impaired.

Related Publications:
a new FGF10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: a novel model for dry-eye disease?
Invest. Ophthalmol. Vis. Sci., Sep 2009; 50: 4311 - 4318.
the homeodomain transcription factor barx2 is required for normal lacrimal gland development and cooperates with FGF10 in regulation of branching morphogenesis
Invest. Ophthalmol. Vis. Sci., Apr 2009; 50: 4236.
progesterone regulates FGF10, met, igfbp1, and igfbp3 in the endometrium of the ovine uterus
Biol Reprod, Dec 2008; 79: 1226 - 1236.
cystic adenomatoid malformations are induced by localized FGF10 overexpression in fetal rat lung
Am. J. Respir. Cell Mol. Biol., Sep 2008; 39: 346 - 355.
specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation
J. Biol. Chem., Apr 2008; 283: 9308 - 9317.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
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by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
Related Products:
product_icon_8.jpg Human Fibroblast Growth Factor 10 Recombinant
product_icon_7.jpg Rabbit anti FGF-10 Polyclonal
 
 
 
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