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Rabbit anti M-CSF Polyclonal

M-CSF

accession:  P09603
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA09603
Applications:
Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
 
Source:
Polyclonal M-CSF antibody was produced from sera of rabbits  immunized with synthetic protein containing M-CSF antigenic determinants. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

M-CSF

M-CSF is produced by monocytes, granulocytes, endothelial cells, and fibroblasts. After cell activation, B-cells and T- cells and also a number of tumor cell lines are capable also of synthesizing this factor. M-CSF has been found to be synthesized by uterine epithelial cells in vivo. The M-CSF receptor is identical with the proto- oncogene fms. It has been renamed CD115. The receptor is a transmembrane protein with an extracellular ligand- binding domain of 512 amino acids, an intramembrane domain of 25 amino acids, and a cytoplasmic domain of 435 amino acids encoding a tyrosine kinase .Human M-CSF is active in mouse and rat cells. The murine factor is active in rat cells but inactive in human cells.M- CSF is a specific factor in that the proliferation inducing activity is more or less restricted to the macrophage lineage. M-CSF is a potent stimulator of functional activities of monocytes.

Related Publications:
gM-CSF and il-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of tnf- converting enzyme (tace)
Blood, Sep 2009; 10.1182/blood-2009-04-215020.
gM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type i interferon signaling
J. Leukoc. Biol., Aug 2009; 86: 411 - 421.
M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis
J. Exp. Med., May 2009; 206: 1089 - 1102.
c-reactive protein induces M-CSF release and macrophage proliferation
J. Leukoc. Biol., Feb 2009; 85: 262 - 267.
M-CSF preferentially induces c-fos via erk to specify monopoiesis whereas g-csf directs granulopoiesis via shp2
Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 2887.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
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