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Rabbit anti BMP-4 Polyclonal

BMP-4

accession:  P12644
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA12644
Applications:
Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
 
Source:
Polyclonal BMP-4 antibody was produced from sera of rabbits  immunized with synthetic protein containing BMP-4 antigenic determinants. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

BMP-4

BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some of the proteins induce the synthesis of alkaline phosphatase and collagen in osteoblasts. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signaling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP4 and BMP7 have been shown to be involved also in the differentiation of sympathetic neurons. They enhance the formation of adrenergic sympathetic neurons in cultures of neural crest cells.

Related Publications:
smad, pi3k/akt, and wnt-dependent signaling pathways are involved in BMP-4-induced esc self-renewal
Stem Cells, Aug 2009; 27: 1858 - 1868.
molecular interaction of BMP-4, tgf-β, and estrogens in lactotrophs: impact on the prl promoter
Mol. Endocrinol., Jul 2009; 23: 1102 - 1114.
suppression of vegf expression and lesion size in laser-induced cnv in a mouse model overexpressing BMP-4
Invest. Ophthalmol. Vis. Sci., Apr 2009; 50: 1193.
altered shear stress stimulates upregulation of endothelial vcam-1 and icam-1 in a BMP-4– and tgf-β1–dependent pathway
Arterioscler Thromb Vasc Biol, Feb 2009; 29: 254 - 260.
the bone morphogenetic protein (bmp)-4 is involved in the regulation of human megakaryocytic differentiation during thrombopoietin signaling.
Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 1339.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
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by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
Related Products:
product_icon_8.jpg Human Bone Morphogenetic protein-4 Recombinant
product_icon_7.jpg Rabbit anti BMP-4 Polyclonal
 
 
 
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