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Rabbit anti BMP-2 Polyclonal

BMP-2

accession:  P12643
   Size A     100ug   $ 190
   Size B      200ug  $290
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA12643
Applications:
Elisa: Use at a concentration range of  1-2ug/ml.
il-2 elisa Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
il-2 elisa IHC: A suitable range of concentrations of this antibody for IHC  is 2-10 µg/ml.
 
Source:
Polyclonal BMP-2 antibody was produced from sera of rabbits  immunized with synthetic protein containing BMP-2 antigenic determinants. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

Serum IgG fraction was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS pH 7.4, 0.1% BSA .
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

BMP-2

BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some of the proteins induce the synthesis of alkaline phosphatase and collagen in osteoblasts. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signaling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP-2 wild type binds to its cellular receptors via two distinct binding epitopes. The large epitope 1 is responsible for the high- affinity binding to the BMPR-IA receptor, the smaller epitope 2 provides the low-affinity binding to the receptor BMPR-II.

Related Publications:
recombinant human BMP-2 enhances local bone formation in the lumbar spine of osteoporotic sheep
J Bone Joint Surg Br Proceedings, Sep 2009; 91-B: 436.
remodeling of chromatin structure within the promoter is important for BMP-2-induced fgfr3 expression
Nucleic Acids Res., Jul 2009; 37: 3897 - 3911.
BMP-2 is a cost-effective therapy in grade iii open tibia fractures – a health-economic assessment of the use BMP-2 in open tibia fractures for european health care systems
J Bone Joint Surg Br Proceedings, Mar 2009; 91-B: 155.
activation of amp kinase and inhibition of rho kinase induce the mineralization of osteoblastic mc3t3-e1 cells through endothelial nos and BMP-2 expression
Am J Physiol Endocrinol Metab, Jan 2009; 296: E139 - E146.
irbesartan attenuates ang ii-induced BMP-2 expression in human umbilical vein endothelial cells
Vascular Medicine, Aug 2008; 13: 239 - 245.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
Related Products:
product_icon_8.jpg Human Bone Morphogenetic protein-2 Recombinant
product_icon_7.jpg Rabbit anti BMP-2 Polyclonal
 
 
 
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