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Human BAFF-R(CD268) Recombinant

BAFF-R

accession:  Q96RJ3
   Size A     10ug   $ 70
   Size B      50ug  $160
   Size C      1mg  $ 1200
Domain  :  BAFFR
Gene  :  TNFRSF13C
Catalog no. :  RKQ96RJ3
Source:
Optimized DNA sequence encoding Human BAFF-R extracellular domain was expressed in Escherichia Coli

 
Molecular weight:
Recombinant human BAFF-R,  is a disulfide-linked monomeric protein consisting of 76 amino acid residue subunits. The molecule has a calculated molecular mass of approximately 9 kDa and migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE.

 
Purity:
>95%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
The ED(50) was determined by the ability to block BAFF induced survival of splenocyte cells, and  was found to be in the range of 1.0-5.0 ug/ml.

 
Protein Sequence:
        10         20         30         40         50         60 
MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ 

        70         80         90        100        110        120 
ESVGAGAGEA ALPLPGLLFG APALLGLALV LALVLVGLVS WRRRQRRLRG ASSAEAPDGD
(*)Complete precursor sequence shown, expressed chain highlighted
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant BAFF-R was lyophilized from a 0.2 μm filtered solution in 2.5% glycine, 0.5% sucrose, 0.01% Tween80, 5 mM Glutamic acid, pH 4.5.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

BAFF-R

The B cell-activating factor from the TNF family (BAFF), is emerging as an important regulator of B cell and T cell responses. BAFF was originally identified as a factor responsible for B cell survival and maturation .BAFF binds to several receptors. These include transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), BAFF-R (BR3), and B cell maturation Ag (BCMA). BAFF-R appears to be particularly important for the regulation of B cell survival and maturation in the spleen, because A/WySnJ mice expressing a defective BAFF-R have disrupted B cell maturation, similar to that seen in BAFF-deficient mice.

Related Publications:
autoantibody-producing rp105– b cells, from patients with systemic lupus erythematosus, showed more preferential expression of bcma compared with BAFF-R than normal subjects
Rheumatology, Jan 2010; 10.1093/rheumatology/kep437.
the effects of baff and BAFF-R-fc fusion protein in immune thrombocytopenia
Blood, Dec 2009; 114: 5362 - 5367.
c-rel in the regulation of BAFF-R expression in malignant human b cells.
Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2400.
p52 activation in monomorphic b-cell post-transplant lymphoproliferative disorders without BAFF-R expression.
Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2932.
adipocytes as immune cells: differential expression of tweak, baff, and april and their receptors (fn14, BAFF-R, taci, and bcma) at different stages of normal and pathological adipose tissue development
J. Immunol., Nov 2009; 183: 5948 - 5956.




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