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Varicella Zoster Virus Glycoprotein E Recombinant

VZV gE

accession:  Q9DWX8
   Size A       $
   Size B      0.5mg  $800
   Size C      1mg  $ 1100
Domain  : 
Gene  :  gp69
Catalog no. :  RKQ9DWX8
Source:
DNA sequence encoding immunodominant  fragment of Varicella Zoster virus Glycoprotein E was expressed in Escherichia Coli.

 
Molecular weight:

Recombinant Varicella Zoster virus gE encodes the immunodominant sequences of the VZV Glycoprotein E. This molecule has a calculated mass of approximately 11kDa.

Recombinant VZV Glycoprotein E contains an N terminal GST purification tag and migrates as an approximately 37 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE.
 
Applications:

VZV gE antigen is suitable for ELISA and Western blots, excellent antigen for detection of VZV with minimal specificity problems.

 

 Specificity:
Immunoreactive with sera of VZV-infected individuals.
 
Presentation:
Lyophilized from 25mM Tris-Hcl pH 8.0, 1mM EDTA and 50% glycerol.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this protein can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This  product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

 

VZV gE

lycoprotein E (gE), type I integral membrane protein, is expressed on plasma membranes and in the cytoplasm of VZV-infected cells, where it is presumed to be present in the membranes of intracellular vesicles or organelles. VZV gE complexes with gI in the rough endoplasmic reticulum, and most gE exists in the form of gE-gI heterodimers in infected cells. VZV gE is also a predominant component of the virion envelope. The functions of gE, which is encoded by ORF68, are of particular interest because it has been demonstrated that ORF68 is essential for VZV replication. ZV gE is predicted to be important for mediating cell-cell spread of the virus as well as for the assembly of intact enveloped virions. Endocytosis of gE is facilitated by gI, and gI regulates the trafficking of the gE-gI complex. VZV gE enhances cell-cell contact in polarized epithelial cells, with or without gI expression.

 




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