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Hepatitis C Virus Nonstructural protein 4 Recombinant

HCV NS4

accession: 
   Size A       $
   Size B      0.5mg  $800
   Size C      1mg  $ 1100
Domain  : 
Gene  :  NS4
Catalog no. :  RKHCVNS4
Source:
DNA sequence encoding immunodominant  fragment of Hepatitis C Virus nonstructural protein 4 was expressed in Escherichia Coli.

 
Molecular weight:

Recombinant HCV NS4 encodes the immunodominant sequences of the HCV nonstructural protein 4A,4B. This molecule has a calculated mass of approximately 6kDa.

Recombinant HCV NS4 contains an N terminal GST purification tag and migrates as an approximately 32 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE.
 
Applications:

HCV NS4 antigen is suitable for ELISA and Western blots, excellent antigen for detection of HCV with minimal specificity problems.

 

Genotypes:

Available HCV NS4 genotypes: 1,2,3,5.

 

 Specificity:
Immunoreactive with sera of HCV-infected individuals.
 
Presentation:
50mM Tris-HCl, pH-8, 60mM NaCl, 10mM glutathione, 0.25% sarkosil & 50% glycerol.

 
 
 
Storage:
This protein can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This  product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

 

HCV NS4

HCV nonstructural NS4A helps to anchor NS3 to the surface of the microsomal membrane by mutual association of these two proteins. Furthermore, the NS3- NS4A complex associates with NS4B, NS5A, and NS5B to form a complex structure which may be involved in virus replication. These observations may imply that NS4A plays an important role in complex formation. Recently, it was reported that NS4A is necessary for cleavage at the 4B-5A site and that it enhances cleavage at NS3- dependent cleavage sites.

 




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Antibodies:
Purified Polyclonal
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