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Hepatitis C Virus Core protein Recombinant

HCV Core

accession: 
   Size A       $
   Size B      0.5mg  $800
   Size C      1mg  $ 1100
Domain  : 
Gene  :  p21
Catalog no. :  RKHCVNCC
Source:
DNA sequence encoding immunodominant  fragment of Hepatitis C Virus core protein was expressed in Escherichia Coli.

 
Molecular weight:

Recombinant HCV Core encodes the immunodominant sequences of the HCV nucleocapsid p21 protein. This molecule has a calculated mass of approximately 13kDa.

Recombinant HCV Core contains an N terminal GST purification tag and migrates as an approximately 39 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE.
 
Applications:

HCV Core antigen is suitable for ELISA and Western blots, excellent antigen for detection of HCV with minimal specificity problems.

 

Genotypes:

Available HCV Core genotypes: 1b,1a,2a,2b,3a,3b,4,5,6a.

 

 Specificity:
Immunoreactive with sera of HCV-infected individuals.
 
Presentation:
 50mM Tris-HCl, pH-8, 60mM NaCl, 10mM glutathione, 0.25% sarkosil & 50% glycerol.

 
 
 
Storage:
This protein can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

 

HCV Core

The capsid is formed by polymerization of the HCV Core protein, a structural viral protein encoded by the 5 end of the HCV open reading frame.1 After translation, host signal peptidases cleave the HCV Core protein from the precursor polyprotein and remove the signal peptide located at its C-terminus. The HCV Core protein is antigenic, interacts with numerous cellular proteins, induces specific cellular and humoral responses, and through various pathways could play an important role in the pathogenesis of HCV infection.

Related Publications:
hepatitis c virus (hcv) infection, monoclonal immunoglobulin specific for HCV Core protein, and plasma-cell malignancy
Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 2712.
transcriptional slippage prompts recoding in alternate reading frames in the hepatitis c virus (hcv) core sequence from strain hcv-1
J. Gen. Virol., Jul 2008; 89: 1569 - 1578.
HCV Core protein interaction with gc1q receptor inhibits th1 differentiation of cd4+ t cells via suppression of dendritic cell il-12 production
J. Leukoc. Biol., Dec 2007; 82: 1407 - 1419.
hepatitis c virus (hcv) core protein-induced, monocyte-mediated mechanisms of reduced ifn- and plasmacytoid dendritic cell loss in chronic hcv infection
J. Immunol., Nov 2006; 177: 6758 - 6768.
simultaneous detection of hepatitis c virus (hcv) core antigen and anti-hcv antibodies improves the early detection of hcv infection
J. Clin. Microbiol., Aug 2005; 43: 3877 - 3883.




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