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Human HER4 (ERBB4) Recombinant , Biotinylated


accession:  Q15303
   Size A     10ug   $ 340
   Size B      25ug  $590
   Size C      100ug  $ 1950
Domain  :  Extracellular
Gene  :  ERBB4
Catalog no. :  RBQ15303
DNA sequence encoding extracellular domain of Human HER4 (ERBB4)  to a C-terminal polyHis tag was expressed in CHO cells.

Molecular weight:

Recombinant Human ERBB4  is a monomer consisting of 635 amino acid residue , and migrates as an approximately 75 kDa protein under reducing conditions in SDS-PAGE.

>95%, as determined by SDS-PAGE

ELISA,WB:  Biotinylated HER4 was designed to be used in single step detection in ELISA ,WB

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant Human ERBB4  was lyophilized from a 0.2 μm filtered PBS  pH 7.4.

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.




ErbB4 is known to have a unique signaling feature among the ErbB-family members. Stimulation with NRG-1, a ligand of ErbB4, not only activates downstream signaling molecules close to or on the cytoplasmic face of the plasma membrane but also cleaves the ErbB4 extracellular domain and the intracellular domain by TNF- α-converting enzyme (TACE) and γ-secretase, respectively Cleavage by TACE removes the extracellular domain and leaves the membrane- associated 80-kDa ErbB4 fragment (m80 ErbB4). The m80 ErbB4 fragment is further cleaved by γ- secretase to release the soluble 80-kDa ErbB4 fragment, termed the ErbB4 intracellular domain (4ICD), into the cytoplasm

Related Publications:
development of gaba circuitry of fast-spiking basket interneurons in the medial prefrontal cortex of ERBB4-mutant mice
J. Neurosci., Dec 2013; 33: 19724 - 19733.
regulation of spine formation by ERBB4 in pv-positive interneurons
J. Neurosci., Dec 2013; 33: 19295 - 19303.
ERBB4 reduces synaptic gabaa currents independent of its receptor tyrosine kinase activity
PNAS, Nov 2013; 110: 19603 - 19608.
cdk5 phosphorylation of ERBB4 is required for tangential migration of cortical interneurons
Cereb Cortex, Oct 2013; 10.1093/cercor/bht290.
neuregulin-1/ERBB4 signaling regulates kv4.2-mediated transient outward k+ current through the akt/mtor pathway
Am J Physiol Cell Physiol, Jul 2013; 305: C197 - C206.

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