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Human Follicle Stimulating Hormone |
FSH |
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| accession: |
P01225 |
| Size A |
2ug |
$70 |
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| Size B |
10ug |
$160 |
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| Size C |
1mg |
$
4700 |
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| Domain : |
cystine knot growth factor |
| Gene : |
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| Catalog no. : |
RKP01225 |
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| Source: |
| Optimized DNA sequence encoding Human FSH mature chain was expressed in CHO. |
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| Molecular weight: |
Follicle stimulating hormoneis a glycoprotein with molecular mass of 30kDa.
FSH is a heterodimeric hormone consisting of 92 amino acids alpha chain and 111 amino acids beta chain. |
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| Purity: |
| >95%, as determined by SDS-PAGE and HPLC |
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| Biological Activity: |
| Activity was determined to be 1x104 IU/mg protein |
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| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg). |
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| Presentation: |
| FSH was lyophilized from a 0.2 μm filtered solution. |
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| Reconstitution: |
| A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
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| Storage: |
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this product can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles. |
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| Usage: |
| This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes. |
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FSH |
Follicle stimulating hormone
(FSH) is a hormone
synthesised and secreted by
gonadotropes in the anterior
pituitary gland. FSH and LH
act synergistically in
reproduction:
In women, in the ovary FSH
stimulates the growth of
immature Graafian follicles
to maturation. As the
follicle grows it releases
inhibin, which shuts off the
FSH production.
In men, FSH enhances the
production of androgen-
binding proteinby the
Sertoli cells of the testes
and is critical for
spermatogenesis.
In both males and females,
FSH stimulates the
maturation of germ cells. In
females, FSH initiates
follicular growth,
specifically affecting
granulosa cells. With the
concomitant rise in inhibin
B FSH levels then decline in
the late follicular phase.
This seems to be critical in
selecting only the most
advanced follicle to proceed
to ovulation. At the end of
the luteal phase, there is a
slight rise in FSH that
seems to be of importance to
start the next ovulatory
cycle.
Like its partner, LH, FSH
release at the pituitary
gland is controlled by
pulses of gonadotropin-
releasing hormone(GnRH).
Those pulses, in turn, are
subject to the estrogen
feed-back from the gonads.
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| Related Publications: |  | the β104–109 sequence is essential for the secretion of correctly folded single-chain β horse lh/cg and for its FSH activity
J. Endocrinol.,
Oct 2009;
203:
167 - 174.
|  | androgen, progesterone, and FSH receptor polymorphisms in ovarian cancer risk and outcome
Endocr. Relat. Cancer,
Sep 2009;
16:
1005 - 1016.
|  | effects of highly purified urinary FSH and human menopausal FSH on uterine myoelectrical dynamics
Mol. Hum. Reprod.,
Aug 2009;
10.1093/molehr/gap076.
|  | a double-blind, non-inferiority rct comparing corifollitropin alfa and recombinant FSH during the first seven days of ovarian stimulation using a gnrh antagonist protocol
Hum. Reprod.,
Aug 2009;
10.1093/humrep/dep291.
| | does the estradiol level on the day of human chorionic gonadotrophin administration have an impact on pregnancy rates in patients treated with rec-FSH/gnrh antagonist?
Hum. Reprod.,
Aug 2009;
10.1093/humrep/dep290.
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