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Human CTLA4 (CD152) Recombinant , Biotinylated


accession:  P16410
   Size A     10ug   $ 340
   Size B      25ug  $590
   Size C      100ug  $ 1950
Domain  :  Extracellular
Gene  :  CTLA4
Catalog no. :  RBP16410
DNA sequence encoding extracellular domain of Human CTLA4  to a C-terminal polyHis tag was expressed in HEK cells.

Molecular weight:

Recombinant Human CTLA4 (CD152)  is a monomer consisting of 137 amino acid residue , and migrates as an approximately 25 kDa protein under reducing conditions in SDS-PAGE.

>95%, as determined by SDS-PAGE

ELISA,WB:  Biotinylated CTLA4 was designed to be used in single step detection in ELISA ,WB

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/┬Ág(1EU/┬Ág).

Recombinant Human CTLA4 was lyophilized from a 0.2 μm filtered PBS  pH 7.4.

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

The lyophilized protein is stable for at least 2 years from date of receipt at -20┬░ C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2┬░ - 8┬░ C for one month, or at -20┬░ C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.




Cytotoxic T lymphocyteľ associated antigen 4 (CTLA4) is an inhibitory receptor expressed on T-cell surface that is induced by T-cell activation to negatively regulate excessive activation of T cells.

Related Publications:
development of gaba circuitry of fast-spiking basket interneurons in the medial prefrontal cortex of ERBB4-mutant mice
J. Neurosci., Dec 2013; 33: 19724 - 19733.
regulation of spine formation by ERBB4 in pv-positive interneurons
J. Neurosci., Dec 2013; 33: 19295 - 19303.
ERBB4 reduces synaptic gabaa currents independent of its receptor tyrosine kinase activity
PNAS, Nov 2013; 110: 19603 - 19608.
cdk5 phosphorylation of ERBB4 is required for tangential migration of cortical interneurons
Cereb Cortex, Oct 2013; 10.1093/cercor/bht290.
neuregulin-1/ERBB4 signaling regulates kv4.2-mediated transient outward k+ current through the akt/mtor pathway
Am J Physiol Cell Physiol, Jul 2013; 305: C197 - C206.

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