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IL-3 family

IL-3 ,IL-5 and GM-CSF constitute an important subfamily of cytokines which play a role in the proliferation and maturation of myeloid cells. All three cytokines have been implicated in maturation of  myeloid cell lineage. IL-5 appears to be particularly important in eosinophil and mast cell biology. IL-5 also plays a role in B cell immune response. IL-3 influences the the proliferation and maturation of  stem cells, as well as progenitors of granulocyte, macrophage and basophil lineages. GM-CSF functions as a growth factor for granulocyte,macrophage and eosinophil lineages.

The receptor consists of alpha (ligand specific) subunit and beta (activating) subunit. The beta chain which associates with JAK2, promotes activation of JAK2 and STAT5 pathways.

 

Molecule Description Catalog #
GM-CSF
product_icon_7.jpg Monoclonal Mouse Anti Human GM-CSF RMA04141
product_icon_8.jpg Human GM-CSF Recombinant RKP04141-1
product_icon_8.jpg Mouse GM-CSF Recombinant RKP01587
product_icon_7.jpg Rabbit anti GM-CSF Polyclonal RPA04141
IL-3
product_icon_8.jpg Human Interleukin-3 Recombinant RKP08700
product_icon_8.jpg Mouse Interleukin-3 Recombinant RKP01586
product_icon_7.jpg Rabbit anti IL-3 Polyclonal RPA08700
IL-5
product_icon_8.jpg Human Interleukin-5 Recombinant RKP05113
product_icon_8.jpg Rat Interleukin-5 Recombinant RKQ08125
product_icon_8.jpg Mouse Interleukin-5 Recombinant RKP04401
product_icon_7.jpg Rabbit anti IL-5 Polyclonal RPA05113




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